PASSCLAIM--diet-related cancer

European Journal of Nutrition
Joseph RafterJan van Loo

Abstract

The role of dietary factors in the aetiology of human cancer is an area, which has attracted intense interest in recent years. The suggestion that approximately one third of all cancers may be caused by an 'inappropriate' balance of food components has led to the attractive contention that we can significantly decrease cancer incidence through dietary recommendations and a change in dietary habits in populations. Thus, a key issue must be to establish clear criteria, which must be met in order to be able to make 'cancer risk reduction' claims for food components. In this area, the one true marker is the malignant human tumour, which for practical reasons is usually not accessible to claims. In its absence, we must rely on alternative markers--biomarkers/surrogate endpoints. This paper mainly deals with the link of these biomarkers to the endpoint tumour and their usefulness for making claims. Some claims have been made based on epidemiological studies. Can we identify targets/ biomarkers in the chain of events from initial 'exposure' to overt malignant tumour, whose modification can be used to make 'anticancer' claims for food components? We identified 18 targets/markers in the above chain of events whose modification 'have the...Continue Reading

Citations

Jun 4, 2005·European Journal of Nutrition·Peter J AggettHans Verhagen
Nov 26, 2009·European Journal of Nutrition·Peter J Aggett
Dec 17, 2011·The British Journal of Nutrition·Stefanie LuxMichael Glei
May 23, 2007·Nutrition and Cancer·Chris I R GillIan Rowland
Nov 28, 2012·BMC Surgery·Mario UccelloAntonio Biondi
Dec 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K T DalyB A Magnuson
Jun 28, 2006·Nutrition and Cancer·Geeta LalaBernadene A Magnuson
Mar 9, 2010·Cadernos de saúde pública·Ana Lucia Araujo de ToledoDirce Maria Lobo Marchioni
Aug 29, 2014·Molecular Nutrition & Food Research·Karen WindeyKristin Verbeke
Aug 26, 2009·Nutrition Reviews·Jennifer R PearsonIan R Rowland
Sep 20, 2005·Alimentary Pharmacology & Therapeutics·C PicardC Matuchansky
Jun 9, 2004·The British Journal of Nutrition·Ian Rowland
Nov 7, 2015·Archives of Toxicology·Isabel Anna Maria GrohMelanie Esselen
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Youngjoo Kwon, Bernadene A Magnuson
Feb 8, 2007·The American Journal of Clinical Nutrition·Joseph RafterJohn K Collins
Oct 24, 2007·The Journal of Nutrition·Beatrice L Pool-Zobel, Julia Sauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.