Passerini/Tsuji-Trost strategies towards achieving lactams and cyclopentane derivatives

Chemical Communications : Chem Comm
Marie CordierNoisette Narboni

Abstract

The Passerini reaction of α,β-unsaturated aldehydes affords suitable substrates for the Tsuji-Trost reaction with various carbon based-nucleophiles. The resulting α,β-unsaturated amides may be cyclized to lactams or converted into cyclopentane derivatives if bis-nucleophiles are used in the Tsuji-Trost step.

References

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Oct 20, 2000·Chemistry : a European Journal·H BienaymeP Schmitt
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Jun 29, 2011·Angewandte Chemie·Eelco RuijterRomano V A Orru
Mar 3, 2012·Chemical & Pharmaceutical Bulletin·Masahiro Yoshida

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Citations

Dec 3, 2016·Chemical Communications : Chem Comm·El Hachemia El MamouniLaurent El Kaïm
Dec 10, 2016·The Journal of Organic Chemistry·Christopher A DiscoloDonald R Deardorff
Sep 13, 2018·Chemical Communications : Chem Comm·Mansour Dolè KerimLaurent El Kaïm

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