Passive avoidance training decreases synapse density in the hippocampus of the domestic chick

The European Journal of Neuroscience
A M NikolakopoulouM G Stewart

Abstract

The bird hippocampus (Hp), although lacking the cellular lamination of the mammalian Hp, possesses comparable roles in spatial orientation and is implicated in passive avoidance learning. As in rodents it can be divided into dorsal and ventral regions based on immunocytochemical, tracing and electrophysiological studies. To study the effects of passive avoidance learning on synapse morphometry in the Hp, spine and shaft synapse densities of 1-day-old domestic chicks were determined in dorsal and ventral Hp of each hemisphere by electron microscopy, 6 and 24 h following training to avoid pecking at a bead coated with a bitter-tasting substance, methyl anthranilate (MeA). The density of asymmetric spine and shaft synapses in MeA-trained birds at 6 h post-training was significantly lower in the dorsal and ventral Hp of the right hemisphere relative to control (untrained) chicks, but by 24 h this difference was absent. A hemispheric asymmetry was apparent in the ventral Hp where the water-trained group showed enhanced shaft and spine synapse density in the left hemisphere, whilst in the MeA-trained group only asymmetric shaft synapses follow the same pattern in relation to the right hemisphere. There were no differences in asymmetr...Continue Reading

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Citations

Feb 8, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie E GibbsRoger J Summers
Nov 13, 2010·Biological Reviews of the Cambridge Philosophical Society·Niels C RattenborgVladimir V Pravosudov
Oct 31, 2015·Brain & Development·Sraboni ChaudhuryShashi Wadhwa
Feb 29, 2008·Hippocampus·Fenghua ChenJens R Nyengaard
Nov 15, 2006·The European Journal of Neuroscience·A M NikolakopoulouM G Stewart
May 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sang-Eun LeeSunghoe Chang
Jun 27, 2021·Neuropharmacology·Dmitri A Rusakov, Michael G Stewart

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