Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats

Frontiers in Systems Neuroscience
Laura A GrafeSeema Bhatnagar

Abstract

Exposure to severe stress has immediate and prolonged neuropsychiatric consequences and increases the risk of developing Posttraumatic Stress Disorder (PTSD). Importantly, PTSD develops in only a subset of individuals after exposure to a traumatic event, with the understanding of this selective vulnerability being very limited. Individuals who go on to develop PTSD after a traumatic experience typically demonstrate sleep disturbances including persistent insomnia and recurrent trauma-related nightmares. We previously established a repeated social defeat paradigm in which rats segregate into either passively or actively coping subpopulations, and we found that this distinction correlates with measures of vulnerability or resilience to stress. In this study, we examined differences between these two behavioral phenotypes in sleep changes resulting from repeated social defeat stress. Our data indicate that, compared to control and actively coping rats, passively coping rats have less slow-wave sleep (SWS) for at least 2 weeks after the end of a series of exposures to social defeat. Furthermore, resilient rats show less exaggerated motor activation at awakenings from rapid eye movement (REM) sleep and less fragmentation of REM slee...Continue Reading

References

Jun 1, 1989·The American Journal of Psychiatry·R J RossS N Caroff
Jan 1, 1972·Ciba Foundation Symposium·G L Engel, A H Schmale
Jan 1, 1995·The American Journal of Psychiatry·T A MellmanB Nolan
Mar 28, 1997·Neuroscience Letters·P MeerloS Daan
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·J M KoolhaasH J Blokhuis
Jul 5, 2001·Physiology & Behavior·P MeerloS Daan
Dec 26, 2001·The New England Journal of Medicine·P Lavie
Oct 3, 2002·The American Journal of Psychiatry·Thomas A MellmanBruce Nolan
Feb 18, 2003·Journal of Neuroendocrinology·A H VeenemaJ M Koolhaas
May 5, 2004·Archives of General Psychiatry·Naomi BreslauTimothy Roehrs
Jul 28, 2006·CNS Spectrums·Thomas A Mellman, Maria Mananita S Hipolito
May 25, 2007·Psychophysiology·Ihori KobayashiDouglas L Delahanty
Jun 5, 2007·Biological Psychiatry·Mitsunari HabukawaHisao Maeda
Aug 25, 2007·Annual Review of Clinical Psychology·Steven M SouthwickDennis S Charney
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Georgina CanoClifford B Saper
Sep 14, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jamie K DaSilvaAdrian R Morrison
Dec 12, 2012·The American Journal of Psychiatry·Anne Germain
Jan 30, 2014·Physiology & Behavior·Anne Marie Kinn RødJanne Grønli
Jun 3, 2015·Biology of Mood & Anxiety Disorders·Edward F Pace-SchottMohammed R Milad
Jul 26, 2015·Neuroscience·R J ChenS Bhatnagar
Jan 1, 2015·Nature Reviews. Disease Primers·Rachel YehudaSteven E Hyman
Jul 5, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Audrey M WellsWilliam A Carlezon
Apr 10, 2018·Trends in Neurosciences·Kristine A WilckensDaniel J Buysse
Apr 4, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Vitor Crestani CalegaroJulia Pinto Trindade
May 6, 2019·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Madhulika A Gupta

❮ Previous
Next ❯

Citations

Feb 3, 2021·Stress : the International Journal on the Biology of Stress·Andrew T GargiuloLaura A Grafe
May 26, 2021·Stress : the International Journal on the Biology of Stress·Yury V LagesJ Landeira-Fernandez

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
Neuroscore
neuro score
GraphPad
R script

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
Ravi Kumar Singareddy, Richard Balon
© 2021 Meta ULC. All rights reserved