Passive exposure of adult cats to moderate-level tone pip ensembles differentially decreases AI and AII responsiveness in the exposure frequency range

Hearing Research
M Pienkowski, J J Eggermont

Abstract

Passive exposure of adult animals to a random ensemble of tone pips band limited between 4 and 20 kHz has been shown to suppress neural activity in primary auditory cortex (AI) to sounds in the exposure frequency range. In the long-term (>3 months), the suppressed neurons can be reactivated by frequencies above and below the exposure range, i.e., tonotopic map reorganization occurs. The suppression can be at least partially reversed after a long period of quiet recovery, as the moderate-level exposure does not impair peripheral hearing. Here we exposed adult cats, for 7-13 weeks without interruption, to two different moderate-level tone pip ensembles, in separate experiments. One exposure stimulus consisted of an octave-wide 2-4 kHz band, which overlaps substantially with the cat vocalization range; the other consisted of a pair of third-octave bands centered at 4 and 16 kHz. We again report a decrease in AI responsiveness in the exposure frequency range, irrespective of the exposure stimulus bandwidth or center frequency, and a slow, partial recovery over a 12-week post-exposure window. In contrast to our previous studies, the suppression in both of the present experiments extended well beyond the exposure frequency range. In ...Continue Reading

References

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Citations

Oct 23, 2012·Ear and Hearing·Jeremy G TurnerBarbara Canlon
Jul 24, 2013·Neuroscience and Biobehavioral Reviews·Larry E RobertsJos J Eggermont
Feb 15, 2011·Neuroscience and Biobehavioral Reviews·Martin Pienkowski, Jos J Eggermont
Feb 5, 2014·Current Opinion in Neurobiology·Christoph E Schreiner, Daniel B Polley
Jun 21, 2014·Nature Reviews. Neuroscience·Boris GourévitchJos J Eggermont
Sep 10, 2019·International Journal of Audiology·Adam SheppardRichard Salvi

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