Passive immunization of hamsters against experimental infection with the Lyme disease spirochete.

Infection and Immunity
R C JohnsonM Russell

Abstract

Hamsters passively immunized with as little as 0.0125 ml of immune rabbit serum (indirect fluorescent-antibody titer, 1:8,192) were protected from challenge with 1,000 50% infective doses of Borrelia burgdorferi. Cross-protection studies with Minnesota and Connecticut isolates of B. burgdorferi indicated no major differences in their capacity to elicit mutually protective antibodies in rabbits.

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