Passive immunization of Nile tilapia (Oreochromis niloticus) provides significant protection against Streptococcus agalactiae

Fish & Shellfish Immunology
David J PasnikPhillip H Klesius

Abstract

A study was conducted to determine the role of specific antibodies in immunity to Streptococcus agalactiae. Adult Nile tilapia (Oreochromis niloticus) were injected i.p. with tryptic soy broth as control or with S. agalactiae vaccine. Ninety days later, fish were challenged with 1.5x10(4)CFUS. agalactiae fish(-1). Blood was drawn from all fish 90d after vaccination and 25d after challenge, and the acquired serum was injected i.p. in fingerling Nile tilapia. These passively immunized fish were subsequently challenged 72h later with 1.5x10(4)CFUS. agalactiae fish(-1), and significantly less (P<0.0001) mortalities were noted among fish administered serum containing specific anti-S. agalactiae antibodies (0.0-10.0% mortalities) than in control groups (63.3-72.7% mortalities). Heat-inactivation of serum produced no significant differences in mortalities than non-heat-treated serum in groups administered serum containing specific antibodies from vaccinated fish (P<0.9455) or vaccinated-challenged fish (P<0.0781). Pre-challenge serum samples indicate that the passively immunized fish had significantly increased (P<0.0001) specific antibody levels over control fish. A highly significant (r(2)=0.5892; P<0.0001) correlation between incre...Continue Reading

Citations

Mar 16, 2013·Veterinary Immunology and Immunopathology·Masatoshi YamasakiAtsushi Yamamoto
Oct 25, 2007·Journal of Molecular Microbiology and Biotechnology·François-Joël Gatesoupe
Mar 31, 2015·Developmental and Comparative Immunology·Xu-liang ZhanWen-sheng Li
May 18, 2016·Veterinary Immunology and Immunopathology·Chris J Hedegaard, Peter M H Heegaard
Sep 24, 2018·Veterinary Immunology and Immunopathology·Tomomasa MatsuyamaChihaya Nakayasu

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