PMID: 7546912Jul 1, 1995Paper

Passive immunization of rhesus macaques against SIV infection and disease

AIDS Research and Human Retroviruses
M B GardnerE Robinson

Abstract

To evaluate the role of humoral immunity against simian immunodeficiency virus (SIV), we tested whether passive immunization with plasma from SIVmac251 vaccine-protected or healthy infected animals would protect rhesus monkeys against intravenous infection with ten 50% animal infectious doses of the cell-free homologous virus. The challenge dose of this SIVmac251 virus stock had previously caused persistent infection in all (21 of 21) nonimmunized controls. A plasma pool was obtained from a donor that had been immunized with an inactivated whole SIVmac251 vaccine produced in human T cells. This plasma pool contained low levels of SIVmac binding and neutralizing antibody but had a high titer of antibodies recognizing human cell proteins. Given 4 or 18 hr before intravenous challenge, this plasma completely protected three of eight recipients from infection and delayed virus detection in one recipient. The five unprotected animals had only a transient or undetectable p27 antigenemia and low virus load in their PBMCs, and all survived at least 7 months after infection. By contrast, no protection was observed in 6 monkeys given inactivated, pooled plasma or purified immunoglobulin (Ig) from healthy SIVmac251-infected animals. This ...Continue Reading

References

Aug 1, 1992·AIDS Research and Human Retroviruses·M GardnerL Giavedoni
Sep 1, 1992·AIDS Research and Human Retroviruses·A J LangloisD P Bolognesi
Aug 1, 1992·AIDS Research and Human Retroviruses·M Murphey-CorbM B Gardner
Jun 1, 1992·AIDS Research and Human Retroviruses·D P Burns, R C Desrosiers
Aug 1, 1991·AIDS Research and Human Retroviruses·A J LangloisD P Bolognesi
Oct 3, 1991·Nature·E J Stott
Jan 1, 1991·AIDS·M B Gardner, S L Hu
Nov 1, 1990·AIDS Research and Human Retroviruses·J R CarlsonM B Jennings
Dec 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M B Gardner, P A Luciw
Jun 7, 1985·Science·M D DanielR C Desrosiers
Feb 11, 1987·Journal of Immunological Methods·M M McKinney, A Parkinson
Feb 1, 1994·Journal of Medical Primatology·M B GardnerM MacKenzie
Jan 1, 1993·AIDS Research and Human Retroviruses·M P CranageP Kitchin

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Citations

Jul 31, 1998·Vaccine·E G HulskotteA D Osterhaus
Oct 12, 2000·Clinics in Dermatology·H Cao, B D Walker
Jun 29, 2002·Current Opinion in Immunology·Flavia Ferrantelli, Ruth M Ruprecht
Aug 1, 1996·Current Opinion in Immunology·R P Johnson
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·D R Burton
Dec 1, 1995·AIDS Research and Human Retroviruses·D C Montefiori
Jan 16, 1998·AIDS Research and Human Retroviruses·M G AgadjanyanD B Weiner
Aug 26, 1998·AIDS Research and Human Retroviruses·L ForesmanS V Joag
Feb 1, 1994·Journal of Medical Primatology·J T Warren, M Dolatshahi
May 1, 1995·Journal of Medical Primatology·J T Warren, M A Levinson
Nov 15, 2011·Annual Review of Medicine·Margaret E AckermanGalit Alter
Jul 14, 2010·Expert Review of Vaccines·George K Lewis
Nov 5, 2008·Expert Review of Vaccines·Sean P McBurney, Ted M Ross
Mar 27, 2002·Journal of Biomedical Science·Stephen M Smith
Jun 18, 1999·Reviews in Medical Virology·A M Geretti

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