Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae

Vaccine
Laura A NovotnyLauren O Bakaletz

Abstract

Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM.

Citations

Dec 6, 2008·The Pediatric Infectious Disease Journal·Timothy F MurphyStephen I Pelton
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Jan 31, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arne ForsgrenHåkan Janson
Jun 3, 2009·Expert Review of Vaccines·Timothy F Murphy
Oct 30, 2009·Expert Review of Vaccines·Roman Prymula, Lode Schuerman
Aug 12, 2009·Vaccine·Lode SchuermanRoman Prymula
Jan 1, 2014·The FEBS Journal·Daniela CordaStefania Mariggiò
Jun 27, 2015·Journal of Immunology Research·Paul T King, Roleen Sharma
May 26, 2017·Critical Reviews in Microbiology·Krishna Bajee SriramAllan W Cripps
Dec 12, 2012·Infection and Immunity·Sarah E Clark, Jeffrey N Weiser
Apr 7, 2017·Clinical and Vaccine Immunology : CVI·Laura A NovotnyLauren O Bakaletz
Mar 20, 2015·Clinical and Vaccine Immunology : CVI·Timothy F Murphy
May 29, 2015·Clinical and Vaccine Immunology : CVI·Laura A NovotnyLauren O Bakaletz

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