Passive opium smoking does not have beneficial effect on plasma lipids and cardiovascular indices in hypercholesterolemic rabbits with ischemic and non-ischemic hearts

Journal of Ethnopharmacology
Hamid NajafipourHamid Reza Nasri

Abstract

To scientifically test a traditionally belief of some Asian countries residents that opium may prevent or have ameliorating effects on cardiovascular diseases (CVD) we investigated the effect of passive opium smoking (POS) on plasma lipids and some cardiovascular parameters in hypercholesterolemic rabbits with ischemic and non-ischemic hearts. 40 rabbits were fed for 2 weeks with cholesterol-enriched diet and divided to control (CTL), short-term opium (SO) and long-term opium (LO) groups. SO and LO groups were exposed to POS for 3 days and 4 weeks respectively. ECG, blood pressure (BP) and left ventricular pressure recorded and serum lipid and cardiac troponin I levels were measured. Isoproterenol (ISO) injected for induction of cardiac ischemia and after 4h the above variables were measured along with cardiac histopathology assessment. HDL cholesterol decreased significantly in LO compared to CTL group (35+/-5 vs 53+/-5mg/dl). Groups treated with ISO showed significantly higher increments in troponin I level (P<0.05) except for LO group and reduction of BP was higher in ISO and SO+ISO groups compared to CTL and SO groups respectively (-38+/-6 vs -23+/-4 and -37+/-11 vs -11+/-3 percent respectively, P<0.05). Reduction in BP was...Continue Reading

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Citations

Oct 23, 2013·Nature Reviews. Cardiology·Farzad MasoudkabirMark J Eisenberg
Apr 24, 2012·Environmental Toxicology and Pharmacology·Hamid Najafipour, Siyavash Joukar
Nov 28, 2018·Journal of Cellular Physiology·Reyhaneh T EbdaliSamira Tabaei
Feb 7, 2014·Endocrine-related Cancer·Lindsay G CarterKevin J Pearson
Apr 19, 2020·Substance Abuse Treatment, Prevention, and Policy·Samaneh NakhaeeOmid Mehrpour

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