Apr 1, 1976

Passive serum sickness in the mouse: the role of vasoactive amines in glomerular deposition of immune complexes

British Journal of Experimental Pathology
P M Ford


This paper reports a study of the importance of vasoactive amines in glomerular localization of passively administered immune complexes in the mouse. Two strains of mice were investigated, one sensitive and the other relatively resistant to the anaphylactogenic effect of intravenously administered immune complexes. The effect on glomerular deposition immune complexes in animals of both strains treated with either vasoactive amine depletors or antagonists leads to the conclusion that in this experimental system vasoactive amines do not play a major part in the glomerular localization of immune complexes.

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Mentioned in this Paper

Serum Sickness
Mice, Inbred DBA
Antihistamines, Classical
Mouse, Inbred ICRC
Immune complex
Serotonin Antagonists

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.