Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement

BMJ : British Medical Journal
Peter H WhincupD G Cook

Abstract

To examine the associations between a biomarker of overall passive exposure to tobacco smoke (serum cotinine concentration) and risk of coronary heart disease and stroke. Prospective population based study in general practice (the British regional heart study). 4729 men in 18 towns who provided baseline blood samples (for cotinine assay) and a detailed smoking history in 1978-80. Major coronary heart disease and stroke events (fatal and non-fatal) during 20 years of follow up. 2105 men who said they did not smoke and who had cotinine concentrations < 14.1 ng/ml were divided into four equal sized groups on the basis of cotinine concentrations. Relative hazards (95% confidence intervals) for coronary heart disease in the second (0.8-1.4 ng/ml), third (1.5-2.7 ng/ml), and fourth (2.8-14.0 ng/ml) quarters of cotinine concentration compared with the first (> or = 0.7 ng/ml) were 1.45 (1.01 to 2.08), 1.49 (1.03 to 2.14), and 1.57 (1.08 to 2.28), respectively, after adjustment for established risk factors for coronary heart disease. Hazard ratios (for cotinine 0.8-14.0 nu > or = 0.7 ng/ml) were particularly increased during the first (3.73, 1.32 to 10.58) and second five year follow up periods (1.95, 1.09 to 3.48) compared with later ...Continue Reading

References

Jan 1, 1992·British Journal of Addiction·M J JarvisC Feyerabend
Nov 1, 1991·British Heart Journal·A G ShaperR Weatherall
Jun 1, 1990·The Journal of Pharmacy and Pharmacology·C Feyerabend, M A Russell
Aug 12, 1989·BMJ : British Medical Journal·D J HoleV M Hawthorne
Feb 1, 1989·American Journal of Public Health·D P SandlerD L Shore
Nov 1, 1987·American Journal of Public Health·M J JarvisY Saloojee
May 1, 1985·American Journal of Epidemiology·C GarlandD L Wingard
Dec 1, 1984·Journal of Epidemiology and Community Health·M JarvisY Salloojee
Jan 1, 1996·Epidemiologic Reviews·N L Benowitz
May 20, 1997·Circulation·I KawachiC H Hennekens
Mar 25, 1999·The New England Journal of Medicine·J HeP K Whelton
Feb 24, 2001·Journal of Public Health Medicine·M WalkerP H Whincup
May 17, 2003·BMJ : British Medical Journal·James E Enstrom, Geoffrey C Kabat

❮ Previous
Next ❯

Citations

May 14, 2005·Preventive Medicine·Bruce N Leistikow, Alexander Tsodikov
Nov 30, 2006·Scandinavian Journal of Public Health·Bo HedbladLars Janzon
Mar 8, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Constantine I VardavasPanagiotis K Behrakis
Jun 16, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzPeyton Jacob
Feb 19, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Maciej Lukasz GoniewiczNeal L Benowitz
Jul 25, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alexander I StibyMarcus R Munafò
Mar 23, 2011·Journal of Public Health·I P OonoJ P Pell
Feb 13, 2007·The Journal of Cardiovascular Nursing·Joaquin Barnoya, Stanton A Glantz
Sep 13, 2012·Cardiology in Review·Andrew DunbarWilliam Frishman
Oct 16, 2004·BMJ : British Medical Journal·Ruoling ChenRoger Tavendale
Feb 8, 2005·BMJ : British Medical Journal·Ichiro Kawachi
Mar 3, 2005·BMJ : British Medical Journal·Konrad Jamrozik
Aug 26, 2006·BMJ : British Medical Journal·Jonathan CampionKen Checinski
Mar 16, 2006·Journal of Epidemiology and Community Health·George ThomsonPhilippa Howden-Chapman
May 30, 2006·Tobacco Control·UNKNOWN GTSS Collaborative Group
Dec 1, 2007·Tobacco Control·M J LópezE Fernández
Sep 4, 2012·Tobacco Control·Erika Avila-TangStephen S Hecht
Sep 2, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neal BenowitzPeyton Jacob
Aug 6, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Ann B NguyenJames A de Lemos
Sep 19, 2008·BMC Cardiovascular Disorders·Stilianos EfstratiadisUNKNOWN International EECP Patient Registry-2 Investigators
Jun 27, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Jiang XieJinwen Wang
May 15, 2013·PloS One·Daniel F MackayJill P Pell
Jun 19, 2010·International Heart Journal·Dong-Bin KimJae-Hyung Kim
Sep 22, 2012·American Journal of Public Health·Wendy MaxYanling Shi
Aug 11, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Nicole EbnerStephan von Haehling
Feb 14, 2006·Journal of Occupational and Environmental Medicine·James RepaceJohn T Bernert
Dec 25, 2012·Current Cardiovascular Risk Reports·Danielle L JoelEric C Donny
May 31, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K KnoblochP M Vogt
Aug 10, 2013·Current Opinion in Cardiology·Markus JuonalaOlli T Raitakari
Aug 13, 2015·European Journal of Public Health·Khaled AwawdiShira Zelber-Sagi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.