PMID: 15222398Jun 30, 2004Paper

Passive smoking elevates neurotrophin levels in tears

Human & Experimental Toxicology
Hajime Kimata

Abstract

The effect of passive smoking on levels of neurotrophin in tears was studied in normal subjects or patients with atopic keratoconjunctivitis (AKC). Basal levels of neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4, in tears were significantly higher in AKC patients than those in normal subjects. Passive smoking had no effect on levels of neurotrophin in tears of normal subjects, while it elevated levels of NGF, BDNF, NT-3 and NT-4 in tears of AKC patients. These results indicate that passive smoking elevates levels of neurotrophin in tears, which in turn may aggravate AKC.

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Citations

Aug 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Gordon W LaurieJason J Nichols
Dec 22, 2012·American Journal of Respiratory Cell and Molecular Biology·Venkatachalem SathishY S Prakash
Feb 25, 2014·Pharmacology & Therapeutics·Y S Prakash, Richard J Martin
Aug 1, 2013·Biochimica Et Biophysica Acta·Pawan K VohraY S Prakash
Jun 9, 2010·Expert Review of Respiratory Medicine·Ys PrakashRichard J Martin
May 31, 2019·Current Opinion in Allergy and Clinical Immunology·Marta SacchettiAlessandro Lambiase
Nov 10, 2017·Current Eye Research·Alexander A ShpakNatalia V Gulyaeva

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