Past medical history and pancreatic cancer risk: Results from a multicenter case-control study

Annals of Epidemiology
P MaisonneuvePeter Boyle

Abstract

To investigate risk factors that may be linked to pancreatic cancer. We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82). Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancrea...Continue Reading

References

Aug 19, 1992·International Journal of Cancer. Journal International Du Cancer·H B Bueno de MesquitaA M Walker
Jan 2, 1991·International Journal of Cancer. Journal International Du Cancer·P GhadirianP Boyle
Dec 2, 1991·International Journal of Cancer. Journal International Du Cancer·H B Bueno de MesquitaP Boyle
Feb 1, 1991·International Journal of Cancer. Journal International Du Cancer·G R HoweA B Miller
Feb 1, 1991·International Journal of Cancer. Journal International Du Cancer·M JainA B Miller
May 30, 1991·International Journal of Cancer. Journal International Du Cancer·W ZatonskiP Boyle
Apr 1, 1989·Journal of Clinical Gastroenterology·J A RosaN N Abourizk
Aug 1, 1995·Pancreas·E FernandezP Boyle
Jul 1, 1995·Gastroenterology·P Bansal, A Sonnenberg
Apr 20, 1994·Journal of the National Cancer Institute·A EkbomJ F Fraumeni
Jul 3, 1996·International Journal of Cancer. Journal International Du Cancer·P BoyleA M Walker
Nov 13, 2002·Gut·D MalkaP Ruszniewski
Aug 9, 2005·Gastroenterology·Suresh T ChariGloria M Petersen
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sara GandiniPatrick Maisonneuve
Nov 16, 2005·Gastroenterology·Tatjana Crnogorac-JurcevicNicholas R Lemoine
Dec 15, 2005·JAMA : the Journal of the American Medical Association·Rachael Z Stolzenberg-SolomonDemetrius Albanes
Jan 6, 2006·International Journal of Cancer. Journal International Du Cancer·Michelle C TurnerParviz Ghadirian
Aug 10, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Furong WangElizabeth A Holly
Jan 15, 2008·Langenbeck's Archives of Surgery·Simona IodiceAlbert B Lowenfels
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andrew R HartIan Harvey
Jun 12, 2008·Cancer Research·Robert R McWilliamsGloria M Petersen
Jul 5, 2008·The Lancet Oncology·Paolo BoffettaKurt Straif
Sep 18, 2009·Cancer Causes & Control : CCC·Paige M BracciElizabeth A Holly

❮ Previous
Next ❯

Citations

Dec 21, 2011·Cancer Immunology, Immunotherapy : CII·Michelle C Turner
Jan 25, 2011·Current Gastroenterology Reports·Julia B Greer, Randall E Brand
Apr 24, 2012·Nutrition and Cancer·Cristina BosettiCarlo La Vecchia
Mar 18, 2011·Pancreas·J Trent MagruderDana K Andersen
Jul 1, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie A RossPhuong L Nguyen
Jul 31, 2012·Endocrine-related Cancer·YunFeng Cui, Dana K Andersen
Aug 16, 2013·World Journal of Gastroenterology : WJG·Raffaele Pezzilli, Nico Pagano
Jul 30, 2014·World Journal of Gastroenterology : WJG·Xiao-Dong HeHai-Tao Zhao
Jan 29, 2014·American Journal of Epidemiology·Leticia NogueiraJill Koshiol
Apr 22, 2014·Surgical Oncology·Giuseppe PreziosiGiuseppe Fusai
Mar 13, 2014·Annals of Surgical Oncology·Pikli BatabyalMehrdad Nikfarjam
Jan 16, 2013·Journal of Environmental and Public Health·Brian G LuckettElizabeth T H Fontham
Jul 14, 2012·Experimental Diabetes Research·Jan TrnaMarkéta Hermanová
Jul 4, 2013·American Journal of Epidemiology·Sara H OlsonUNKNOWN Pancreatic Cancer Case-Control Consortium
Dec 14, 2011·Molecular Carcinogenesis·Sara H Olson
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Loren LipworthEva Negri
May 17, 2012·Journal of Surgical Oncology·Sara H Olson, Robert C Kurtz
Jul 1, 2015·International Journal of Surgery·Teresa SalvatoreFerdinando Carlo Sasso
Mar 5, 2014·Critical Reviews in Clinical Laboratory Sciences·Katerina OikonomopoulouEleftherios P Diamandis
Aug 31, 2014·Leukemia Research·C MusolinoS Gangemi
Jul 5, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Soriba Naby CamaraChun-You Wang
Jul 28, 2016·Cancer Letters·Shallu MidhaPramod Kumar Garg
Jan 10, 2018·International Journal of Cancer. Journal International Du Cancer·Brian Z HuangVeronica Wendy Setiawan
Jan 27, 2012·Diabetes/metabolism Research and Reviews·Dana K Andersen
Nov 23, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jemma Ahn, Jong Kyun Lee
Aug 11, 2016·F1000Research·Evan TideringtonCynthia W Ko
Mar 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Raghuwansh P SahSuresh T Chari
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Gui-Xian TongDe-Bin Wang
Jul 1, 2015·Current Opinion in Gastroenterology·Juris J Meier, Arnd Giese
Apr 24, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Valentina RosatoCarlo La Vecchia
Aug 12, 2020·Journal of Experimental & Clinical Cancer Research : CR·Stefano MeniniGiuseppe Pugliese
Feb 21, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Dana K Andersen
Aug 3, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Valentina RosatoCarlo La Vecchia
Dec 3, 2015·Gut·Paulina Gomez-RubioUNKNOWN PanGenEU Study Investigators
Oct 30, 2020·Frontiers in Public Health·Guannan WangBeibei Yu
Mar 29, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katerina OikonomopoulouEleftherios P Diamandis
Feb 21, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michelle CotterchioSteven Gallinger
Jan 20, 2021·Clinical and Translational Gastroenterology·Anna Evans PhillipsGeorgios I Papachristou
Jan 21, 2021·Cancers·Stefano MeniniGiuseppe Pugliese
Jul 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BosettiC La Vecchia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.