Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study

The British Journal of Ophthalmology
Myra B McGuinnessRobert P Finger

Abstract

To assess the association between past physical activity and early, intermediate and late age-related macular degeneration (AMD) in a community-based cohort study in Melbourne, Australia. Diet and lifestyle information was recorded at baseline (1990-1994) and total recreational activity was derived from walking, vigorous and non-vigorous exercise. At follow-up (2003-2007), digital macular photographs were graded for early, intermediate and late AMD. Data were analysed using multinomial logistic regression controlling for age, sex, smoking, region of descent, diet and alcohol. Effect modification by sex was investigated. Out of 20 816 participants, early, intermediate and late AMD were detected at follow-up in 4244 (21%), 2661 (13%) and 122 (0.6%) participants, respectively. No association was detected between past total recreational physical activity and early, intermediate or late AMD. Frequent (≥3 times/week) and less frequent (1-2 times/week) vigorous exercise were associated with lower odds of intermediate and late AMD in univariable models. After controlling for confounders, there was evidence of effect modification by sex and frequent vigorous exercise was associated with a 22% decrease in the odds of intermediate AMD (95...Continue Reading

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Citations

May 28, 2017·American Journal of Ophthalmology·Myra B McGuinnessRobert P Finger
Oct 20, 2018·Acta Ophthalmologica·Ya Xing WangJost B Jonas
Feb 27, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Thomas J HeesterbeekAnneke I den Hollander
Apr 1, 2017·Journal of Hypertension·Yi YangPierre-Antoine Dugué
Mar 23, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M HeinemannR P Finger
Dec 5, 2019·Restorative Neurology and Neuroscience·Hong-Ying LiKwok-Fai So
Apr 4, 2018·Eye·Sharon R OngPradeep Y Ramulu
Oct 26, 2021·American Journal of Ophthalmology·Matthias M MauschitzUNKNOWN European Eye Epidemiology (E3) Consortium

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