Past, Present, and Future of Pharmacologic Therapy in Obesity

Primary Care
José E Rodríguez, Kendall M Campbell

Abstract

Medications for obesity management can be divided into 4 groups: antidepressants (naltrexone/bupropion), stimulants (phentermine, phendimetrazine, diethylpropion, phentermine/topiramate), fat blockers (orlistat), and diabetes medications (liraglutide). Each group has specific therapeutic effects, adverse effects, and costs. Two medications are indicated for long-term use in obesity: lorcaserin and orlistat. Other available medications are for short-term use. High cost makes many of these medications inaccessible for underserved and poor patients. Because of misuse potential, many obesity medications are also classified as controlled substances. There are no medications currently approved for use in pregnant or lactating women.

References

Apr 6, 2005·Annals of Internal Medicine·Zhaoping LiSally C Morton
Jul 22, 2010·The New England Journal of Medicine·Steven R SmithUNKNOWN Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM) Study Group
Jul 9, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Johann GrundlinghDavid M Wood
Jun 27, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ji Won KimWoo Seong Kim
Nov 14, 2013·Journal of the American Pharmacists Association : JAPhA
Dec 23, 2014·Expert Opinion on Drug Safety·Bruno Halpern, Alfredo Halpern
Jan 8, 2015·Cell Metabolism·Aaron M CypessGerald M Kolodny
Apr 16, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Farah E KhorassaniShauna Garris
Jun 25, 2015·Drugs·Sarah L Greig, Gillian M Keating

❮ Previous
Next ❯

Citations

Jun 9, 2016·Journal of Agricultural and Food Chemistry·Giosuè CostaStefano Alcaro
Feb 15, 2018·Journal of Dietary Supplements·Mesfin YimamQi Jia
May 24, 2019·Journal of Medicinal Food·Mesfin YimamQi Jia
Sep 1, 2016·Expert Review of Endocrinology & Metabolism·Robin L BlackLisa M Chastain
Nov 9, 2017·Journal of Medicinal Chemistry·Javier García-CárcelesMaría L López-Rodríguez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Menopausal Medicine
Jong Kil Joo, Kyu Sup Lee
Current Medical Research and Opinion
R H McKay
Annals of the New York Academy of Sciences
George A Bray, Donna H Ryan
© 2022 Meta ULC. All rights reserved