Pasteurella multocida infections in mice with reference to haemorrhagic septicaemia in cattle and buffalo

Immunology and Cell Biology
RamdaniB Adler

Abstract

Haemorrhagic septicaemia (HS) is an infectious disease of cattle and buffalo caused by particular serotypes of Pasteurella multocida and is one of the most economically important livestock diseases in South-East Asia. While HS has been recognized for many years, very little is understood about the disease, primarily because of the expense of cattle and a lack of suitable animal models. The suitability of using mice to study HS was assessed using parameters such as the critical pathogenic dose, kinetics of infection, pathology of disease and resistance to reinfection. Pasteurella multocida M1404, the type strain for Carter group B, the serotype responsible for Asian HS, was injected intraperitoneally into BALB/c mice. As few as 20 colony forming units produced an overwhelming septicaemia in mice in less than 30 h. The kinetics of infection demonstrated a very rapid in vivo multiplication rate. There was no evidence of inhibition of bacterial cell growth by natural host defence mechanisms, even with the very small inocula used. The gross pathology of the disease in mice was characterized by splenomegaly, lymphadenopathy and petechial haemorrhages similar to that observed in cattle and buffalo with HS. Mice were found to develop a...Continue Reading

References

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Citations

Jun 17, 2011·Animal Health Research Reviews·S B ShivachandraA A Kumar
Jun 1, 1991·Australian Veterinary Journal·M J CarriganA T Hansen
Nov 26, 2015·The Journal of Veterinary Medical Science·Nitwarat RuennarongSaranya Poapolathep
Apr 17, 2021·Biologicals : Journal of the International Association of Biological Standardization·Shazwani MohamedKesaven Bhubalan
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Elizabeth A ClemmonsJohn W Dutton

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