Pasteurella multocida toxin interaction with host cells: entry and cellular effects.

Current Topics in Microbiology and Immunology
Brenda A Wilson, Mengfei Ho

Abstract

The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.

Citations

Jul 5, 2013·Clinical Microbiology Reviews·Brenda A Wilson, Mengfei Ho
Dec 5, 2015·Frontiers in Microbiology·Dagmar HildebrandKatharina F Kubatzky
May 23, 2018·Infection and Immunity·Nathan C ClemonsBrenda A Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.