Pasteurized Donor Human Milk Maintains Microbiological Purity for 4 Days at 4°C

Journal of Human Lactation : Official Journal of International Lactation Consultant Association
Amy Manning VickersDavid S Newburg

Abstract

Most protective components in human milk are stable during prolonged storage at 4ºC; however, pasteurization reduces some microbicidal activities responsible for suppressing microbial growth and protecting against infection. Donor milk used by neonatal intensive care units (NICUs) is frozen pasteurized donor human milk (PDHM) defrosted and stored at 4ºC. Current Human Milk Banking Association of North America (HMBANA) Best Practice guidelines recommend that milk be discarded 24 hours after being thawed, but experimental data on the duration of microbiological purity in thawed PDHM are sparse. This study evaluates microbiological purity of thawed PDHM during prolonged storage at 4ºC. A total of 42 independent, randomly selected PDHM samples were thawed at 4ºC. As is typical in NICUs, each bottle was opened at 3-hour intervals and 3 mL was withdrawn with a sterile syringe and transferred into a sterile tube. The 3 mL samples removed at 0, 24, 48, 72, 96 hours, and 9 days were tested for the presence of any microorganisms by a clinical laboratory that routinely screens PDHM for microbes. No evidence of microbial growth was observed in cultured samples taken at 0 to 9 days after thawing of the milk samples. There was no evidence of...Continue Reading

References

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Citations

Oct 19, 2016·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Ting MengApril D Fogleman
Jan 14, 2017·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Andrea Tobío-GimenoCarmen Rosa Pallás-Alonso
Aug 28, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Hannah R Schlotterer, Maryanne T Perrin
Aug 9, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Kaitlin H DrouinMandy B Belfort
May 21, 2019·Journal of Pediatric Gastroenterology and Nutrition·Hannah R SchlottererMaryanne T Perrin
Dec 10, 2019·Pediatric Research·Anshu A PaulMohan Pammi
Jun 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Cosmina MandruBoriana Parvez
Oct 13, 2015·Clinical Obstetrics and Gynecology·David S Newburg, Yingying He

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Software Mentioned

R
R Foundation for Statistical Computing

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