Patch test dose-response study of p-phenylenediamine: thresholds and anatomical regional differences

Contact Dermatitis
Heidi SostedJ D Johansen

Abstract

The elicitation response in allergic contact dermatitis for the hair dye substance p-phenylenediamine (PPD) is dose dependent, but threshold concentrations have not previously been investigated. 15 PPD-sensitive patients participated in a serial dilution 48-hr patch test with PPD using 8 concentrations of PPD ranging from 1 to 10 000 on the upper back. Petrolatum was applied as control. Three concentrations (50, 100 and 500 p.p.m. PPD) were also applied to the retroauricular area and on the lateral aspects of the upper arms. 14 of the 15 participants reacted to one or more of the test samples. The threshold value for 10% of the tested persons (ED10) based on+or stronger reactions for PPD on the back was 38 p.p.m. (CI: 4.3-100). There were no statistically significant differences in the sensitivity of the three anatomical regions. The upper back is a suitable region for patch testing patients with hair dye dermatitis.

References

Aug 1, 1994·Contact Dermatitis·G A van Strien, M J Korstanje
Sep 24, 1998·Contact Dermatitis·J P McFaddenD A Basketter
Mar 12, 2002·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·Ronald R BrancaccioDavid E Cohen
Nov 9, 2002·Contact Dermatitis·J M HextallJ P McFadden
Jun 4, 2005·Contact Dermatitis·Heidi Søsted, Torkil Menné
Jul 21, 2005·The British Journal of Dermatology·H SøstedJ D Johansen

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Citations

Mar 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Suhan Gunasti, Varol Lutfu Aksungur
Jul 31, 2007·Critical Reviews in Toxicology·Hermann M Bolt, Klaus Golka
Aug 20, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M WormA Schnuch
Jun 4, 2014·The British Journal of Dermatology·L M PotB Blömeke
Aug 11, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Pieter-Jan CoenraadsMaya Krasteva
May 23, 2019·Journal of Cosmetic Dermatology·Kiranjeet KaurIndu Bala
Sep 18, 2007·Current Opinion in Allergy and Clinical Immunology·Jochen Brasch
Sep 21, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Pieter-Jan CoenraadsMaya Krasteva
May 10, 2007·Current Opinion in Allergy and Clinical Immunology

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