PMID: 8957330Sep 1, 1996Paper

Patch testing in an aged population without dermatitis: high prevalence of patch test positivity

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
H C MangelsdorfE F Sherertz

Abstract

Epidermal immune function has been observed to decline in the aged. The purpose of this study was to determine the prevalence and relevance of patch test reactivity in an aged population without dermatitis and compare this with patch test reactivity in healthy younger volunteers. Patch testing with the North American Contact Dermatitis Group standard tray was performed on 82 healthy volunteers ranging in age from 68 to 87 years (mean age, 75 years), and the results were compared with those of 41 healthy younger volunteers (mean age, 24 years). A questionnaire regarding cutaneous symptoms was administered to both groups. Thirty subjects in the older population (37%) had one or more positive patch test results compared with 6 members of the control group (15%) (P = .01). Common sensitizers in the older group included balsam of Peru (7[9%]), fragrance (8[10%]), neomycin (6[7%]), nickel (5[6%]), and methylchloroisothiazolinone/methylisothiazolinone (3[4%]). A history of severe pruritus (without dermatitis) was associated with positive patch test results to balsam of peru and nickel. A high prevalence of positive patch test results in an aged population without dermatitis was observed. Factors contributing to to the high prevalence ...Continue Reading

References

Nov 1, 1990·The British Journal of Dermatology·A B CuaH I Maibach
Jan 1, 1989·International Journal of Dermatology·C L Goh
Dec 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·K V RoskosR H Guy
Sep 1, 1986·Contact Dermatitis·S WaltonK Keczkes
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Mar 1, 1953·The Journal of Allergy·M SCHWARTZ

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Citations

Oct 7, 2004·Aging Clinical and Experimental Research·Stefano PiasericoUNKNOWN North-East Italy Contact Dermatitis Group
Jun 16, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Reich-SchupkeM Stücker
Jun 11, 2016·The British Journal of Dermatology·M D LynchP Banerjee

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