Patch testing of experimentally sensitized beagle dogs: development of a model for skin lesions of atopic dermatitis

Veterinary Dermatology
T OlivryC McCall

Abstract

In humans with atopic dermatitis (AD), the epicutaneous application of allergens (atopy patch tests or APT) to which the patients are sensitized often results in the development of inflammation resembling that of spontaneous skin lesions. Dogs are affected with a natural homologue of human AD, but information on the induction of positive patch testing reactions is limited. The objectives of this pilot study were to determine the nature and cellular dynamics of inflammation occurring after APT in dogs hypersensitive to house dust mite and flea allergens. Laboratory Beagles were sensitized experimentally to Dermatophagoides farinae house dust mites (two dogs), Ctenocephalides felis flea saliva (one dog) or both (two dogs). Two other dogs served as nonsensitized controls. Both allergens and saline were applied epicutaneously. Macroscopic evaluations and skin biopsies were performed at 4, 24, 48 and 96 h after starting allergenic challenge. Biopsies were evaluated histologically and immunohistochemically with a panel of monoclonal antibodies specific for canine leucocyte antigens. Positive macroscopic reactions consisted of erythema, oedema and induration, and they occurred between 24 and 96 h after allergen application. Macroscopi...Continue Reading

References

Jun 1, 1990·The Journal of Investigative Dermatology·P DupuyM Bagot
Jan 1, 1986·Archives of Dermatological Research·C Bruynzeel-KoomenP L Bruynzeel
Mar 1, 1995·Allergy·G C MuddeC A Bruijnzeel-Koomen
Jan 1, 1994·Lancet·M GreweJ Krutmann
Oct 23, 1997·The American Journal of Dermatopathology·T OlivryP F Moore
Sep 15, 1999·Allergy·M S de Bruin-WellerC A Bruijnzeel-Koomen
Dec 21, 2000·Clinical and Experimental Dermatology·K Thestrup-Pedersen
Apr 9, 2001·Veterinary Immunology and Immunopathology·K StedmanD Wassom
Sep 13, 2001·Veterinary Immunology and Immunopathology·T OlivryC A Sousa
Sep 13, 2001·Veterinary Immunology and Immunopathology·T Olivry, P B Hill
Nov 14, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·V IngordoA Tortora
Apr 23, 2003·Clinics in Dermatology·Rosanna Marsella, Thierry Olivry
Jun 7, 2003·Veterinary Dermatology·T OlivryUNKNOWN International Task Force on Canine Atopic Dermatitis
Jun 4, 2004·Current Allergy and Asthma Reports·Karin KerschenlohrAndreas Wollenberg

❮ Previous
Next ❯

Citations

May 20, 2008·Immunogenetics·Frank A Looringh van BeeckIldiko Van Rhijn
Aug 3, 2010·Journal of Clinical Immunology·Meret Elisabeth RicklinArtur Summerfield
Feb 24, 2016·Clinics in Dermatology·Cherie M Pucheu-Haston
Feb 4, 2012·Veterinary Immunology and Immunopathology·Simone BethlehemRalf S Mueller
Oct 13, 2009·Veterinary Immunology and Immunopathology·Bruce Hammerberg
Jun 12, 2009·The Journal of Investigative Dermatology·Rosanna Marsella, Giampiero Girolomoni
Sep 12, 2008·Veterinary Immunology and Immunopathology·Chanettee ChanthickKrissanee Buathet
Oct 9, 2007·Journal of Comparative Pathology·K TaglingerA P Foster
Mar 1, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C M Pucheu-HastonB Hammerberg
Mar 19, 2011·Veterinary Dermatology·Rosanna MarsellaUNKNOWN International Task Force on Canine Atopic Dermatitis
Apr 5, 2013·Journal of Veterinary Internal Medicine·V BruetJ C Desfontis
Mar 27, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonMelissa N C Eisenschenk
Feb 14, 2015·Veterinary Dermatology·Petra BizikovaCherie M Pucheu-Haston
Mar 3, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonRosanna Marsella
Mar 3, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonTim Nuttall
Apr 24, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Cevayir CobanShizuo Akira
Jun 28, 2016·The Journal of Investigative Dermatology·Thierry OlivryJavier Cote-Sierra
May 29, 2013·Experimental Dermatology·Thierry OlivryGil Yosipovitch
Oct 27, 2017·Veterinary Medicine and Science·Cindy L ZulegerMark R Albertini
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huali JinBin Wang
Jan 21, 2021·Veterinary Dermatology·Richard HalliwellThierry Olivry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.