Patch Testing to Diphenylguanidine by the North American Contact Dermatitis Group (2013-2016).

Dermatitis : Contact, Atopic, Occupational, Drug
Erin M WarshawMatthew J Zirwas

Abstract

Carba mix (CM, 3% petrolatum) contains 1,3-diphenylguanidine (DPG, 1%), zinc diethyldithiocarbamate (1%), and zinc dibutyldithiocarbamate (1%). Because DPG is a component of CM, DPG is often not tested separately. The purpose of this study was to determine the frequency of concomitant reactions to CM and DPG. A retrospective analysis of the 2013-2016 North American Contact Dermatitis Group data was conducted. The study group consisted of patients with final interpretation of "allergic" to either DPG or CM. Reactions coded as irritant or doubtful/macular erythema (+/- and not interpreted as allergic) were excluded. A total of 10,457 patients were patch tested to both CM and DPG, and 610 (5.8%) had allergic reactions to either CM or DPG (CM only [n = 292, 47.9%], DPG only [n = 190, 31.1%], both [n = 128, 21.0%]). A total of 39.4% of CM-allergic patients reacted to DPG, and 59.7% of DPG-allergic patients reacted to CM. Analyses found that 25% (++/+++ subgroup) to 40% (all patients) of allergic reactions to DPG would have been missed by testing to CM alone. More than 70% of reactions to CM and DPG were +/- or +. Patch testing to CM will miss 25% to 40% of positive reactions to DPG. Both CM and DPG have a high frequency of +/- and +...Continue Reading

References

Feb 1, 1991·Journal of the American Academy of Dermatology·M T BousemaT van Joost
Oct 1, 1989·Journal of the American Academy of Dermatology·R GollhausenJ Ring
Nov 1, 1988·Contact Dermatitis·K E AndersenI R White
Apr 24, 1999·The British Journal of Dermatology·J F BourkeI S Foulds
Mar 19, 2003·Contact Dermatitis·Johannes GeierUNKNOWN Information Network of Departments of Dermatology (IVDK)
Jan 24, 2006·Contact Dermatitis·G PiskinJ D Bos
Sep 2, 2008·Contact Dermatitis·Itai ChipindaPaul D Siegel
Jul 6, 2012·Contact Dermatitis·Johannes GeierAxel Schnuch
Sep 14, 2013·Dermatitis : Contact, Atopic, Occupational, Drug·Erin M WarshawFrances J Storrs
Jun 7, 2016·Contact Dermatitis·Charlotte G MortzKlaus E Andersen
Sep 17, 2016·Contact Dermatitis·Kristiina Aalto-Korte, Maria Pesonen
Dec 23, 2016·European Journal of Dermatology : EJD·Marie-Noëlle Crepy
Feb 9, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Peter C SchalockChristen Mowad
Mar 2, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Molly C GoodierSara A Hylwa
Jun 15, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Anna E KershSalma de la Feld
Jan 15, 2019·Journal of the American Academy of Dermatology·Erin M WarshawJoel G DeKoven

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Citations

Mar 24, 2021·Journal of the American Academy of Dermatology·Joel G DeKovenD Linn Holness

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