Patched, the receptor of Hedgehog, is a lipoprotein receptor

Proceedings of the National Academy of Sciences of the United States of America
Ainhoa CallejoIsabel Guerrero

Abstract

The Hedgehog (Hh) family of secreted signaling proteins has a broad variety of functions during metazoan development and implications in human disease. Despite Hh being modified by two lipophilic adducts, Hh migrates far from its site of synthesis and programs cellular outcomes depending on its local concentrations. Recently, lipoproteins were suggested to act as carriers to mediate Hh transport in Drosophila. Here, we examine the role of lipophorins (Lp), the Drosophila lipoproteins, in Hh signaling in the wing imaginal disk, a tissue that does not express Lp but obtains it through the hemolymph. We use the up-regulation of the Lp receptor 2 (LpR2), the main Lp receptor expressed in the imaginal disk cells, to increase Lp endocytosis and locally reduce the amount of available free extracellular Lp in the wing disk epithelium. Under this condition, secreted Hh is not stabilized in the extracellular matrix. We obtain similar results after a generalized knock-down of hemolymph Lp levels. These data suggest that Hh must be packaged with Lp in the producing cells for proper spreading. Interestingly, we also show that Patched (Ptc), the Hh receptor, is a lipoprotein receptor; Ptc actively internalizes Lp into the endocytic compartme...Continue Reading

References

Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Sep 1, 1996·Insect Biochemistry and Molecular Biology·K SundermeyerM A Wells
Jun 17, 1999·Trends in Cell Biology·A M van der Bliek
Jan 4, 2001·Cell·E V EntchevM González-Gaitán
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Apr 5, 2002·Trends in Genetics : TIG·Patricia E Kuwabara, Michel Labouesse
Apr 20, 2002·The Journal of Biological Chemistry·Robert A McCarthyW Scott Argraves
Jul 19, 2002·Current Biology : CB·John P IncardonaHenk Roelink
Dec 7, 2002·Nature Neuroscience·Karen LaiDavid V Schaffer
Apr 5, 2003·Current Biology : CB·Sebastian GrönkeRonald P Kühnlein
May 6, 2003·Genes & Development·Alan Jian ZhuMatthew P Scott
Jan 23, 2004·Nature Reviews. Cancer·Marina Pasca di Magliano, Matthias Hebrok
May 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Carsten PetersHerbert Waldmann
Jun 11, 2004·Annual Review of Biochemistry·Randall K Mann, Philip A Beachy
May 6, 2005·Nature·Daniela PanákováSuzanne Eaton
Jul 26, 2005·Journal of Neurobiology·Carlos TorrojaIsabel Guerrero
Jan 10, 2006·Cell Metabolism·Jae Myoung SuhJonathan M Graff
Oct 19, 2006·Nature Reviews. Genetics·Philip W Ingham, Marysia Placzek
Nov 28, 2006·Trends in Cell Biology·Isabel Guerrero, Chin Chiang
Jul 5, 2007·Developmental Cell·Christina EugsterSuzanne Eaton

❮ Previous
Next ❯

Citations

Jul 9, 2013·Physics of Life Reviews·M VerbeniJ Soler
Jul 2, 2008·Nature Cell Biology·Dong Yan, Xinhua Lin
May 31, 2013·Nature Reviews. Molecular Cell Biology·James Briscoe, Pascal P Thérond
Dec 24, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Mohamad El-ZaatariJuanita L Merchant
May 8, 2008·Current Opinion in Lipidology·Matts D Linder, Elina Ikonen
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Dong Yan, Xinhua Lin
Jan 11, 2013·International Journal of Molecular Sciences·Joanna SzkanderaMartin Pichler
Jan 5, 2011·Chinese Journal of Cancer·Hailan LiuJingwu Xie
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Katherine W Rogers, Alexander F Schier
Jun 12, 2013·Current Opinion in Genetics & Development·Ana-Citlali Gradilla, Isabel Guerrero
Jan 15, 2016·Cellular and Molecular Life Sciences : CMLS·Tatiana Gorojankina
Apr 24, 2012·Hematology/oncology Clinics of North America·Deirdre J Cohen
May 31, 2011·Progress in Lipid Research·Ronald P Kühnlein
Jan 25, 2011·Trends in Cell Biology·Armel Gallet
Mar 9, 2010·Trends in Cell Biology·Katie L Ayers, Pascal P Thérond
May 16, 2009·Current Opinion in Genetics & Development·Josefa Steinhauer, Jessica E Treisman
Aug 2, 2008·Current Opinion in Genetics & Development·Ma Félix Bastida, Marian A Ros
Aug 21, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Monireh DashtiFarhad Rezaee
Jul 17, 2010·American Journal of Medical Genetics. Part a·M Michael Cohen
Jan 1, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Jan L Christian
Apr 3, 2016·Development Genes and Evolution·Daniel Aguilar-HidalgoFernando Casares
Jul 27, 2012·Current Opinion in Pharmacology·Natalia A Riobo
May 28, 2014·Seminars in Cell & Developmental Biology·Raffaele TeperinoJohn Andrew Pospisilik
Jul 6, 2014·Seminars in Cell & Developmental Biology·Isabel Guerrero, Thomas B Kornberg
Mar 17, 2009·Developmental Biology·Katie L AyersPascal Thérond
Jan 7, 2015·Archives of Toxicology·Yanfei JiaJingwu Xie
Sep 15, 2016·PLoS Computational Biology·Patrick FriedDagmar Iber
Mar 5, 2013·International Journal of Molecular Sciences·Gonzalo P SolisVladimir L Katanaev
May 17, 2018·Essays in Biochemistry·Ana-Citlali GradillaIsabel Guerrero
Aug 1, 2010·Biomolecular Concepts·Dick J Van der Horst, Kees W Rodenburg
Jul 12, 2017·Annual Review of Cell and Developmental Biology·Kostadin PetrovAdrian Salic
Mar 15, 2016·Frontiers in Biology·Kai Jiang, Jianhang Jia
Mar 29, 2019·Development·Diana García-MoralesFernando Casares
Dec 14, 2018·Genetics·Christoph Heier, Ronald P Kühnlein
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Dominique ManikowskiKay Grobe
Dec 24, 2020·Development·Elodie PrincePascal P Thérond
Feb 3, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Yuan GuGuangxu He
Feb 23, 2021·PLoS Computational Biology·Daniel J A DerrickMarcus John Tindall
Nov 13, 2009·Development·Helena KhaliullinaSuzanne Eaton
Jul 27, 2021·Development·Elodie PrincePascal P Thérond

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.