Patches: Established and Emerging Transdermal Treatments in Psychiatry

The Journal of Clinical Psychiatry
Leslie CitromeChristoph U Correll

Abstract

Transdermal delivery is an alternative to oral routes of drug administration and has made considerable contributions to the treatment of various medical diseases. With the advent of new transdermal delivery technologies, higher numbers of medications are being approved for use as transdermal formulations. This route of administration has several innate advantages that have the potential to benefit various patient populations, including those with central nervous system disorders. The current review briefly outlines the history of transdermal medications, discusses the advantages and disadvantages of transdermal formulations, and examines the challenges and opportunities present for the use of transdermal treatments in psychiatry. Patients with psychiatric illnesses have many unmet needs that may be filled through the benefits gained from transdermal treatments, such as reduced dosing frequency, effective control of plasma medication concentrations, improved tolerability, ability to check compliance visually, and avoidance of first-pass hepatic metabolism. Established transdermal treatments for various psychiatric diseases are discussed followed by an introduction to therapies that are being developed as the first patch formulat...Continue Reading

Citations

Sep 19, 2020·Patient Preference and Adherence·Brennan Carrithers, Rif S El-Mallakh

Related Concepts

Mental Disorders
Pharmaceutical Preparations
Plasma
Psychiatry Specialty
Schizophrenia
Health Care
Systemic Disease
Drug Interactions
Heart Alternation
Population Group

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