Patch/matrix patterns of gray matter differentiation in the telencephalon of chicken and mouse

Brain Research Bulletin
Christoph RediesLuis Puelles

Abstract

The mammalian striatum, a subpallial area, consists of two compartments (patches/striosomes and matrix) that differ in their neuronal birth dates, connectivity, neurochemistry, and molecular make-up. For example, members of the cadherin family of adhesion molecules (cadherin-8 and OL-protocadherin) are differentially expressed by the striosomes and the striatal matrix. A patch/matrix type of organization also has recently been found in the ventral hyperstriatum and the neostriatum of the chicken pallium, where cell clusters of similar birthdates ("isochronic" clusters) are surrounded by a matrix of cells that are born at a different time. Immunostaining with antibodies against cadherins reveals a similar arrangement of cell clusters. In the avian neostriatum, cadherin-7-positive cell clusters ("islands") are surrounded by a matrix of cells that express R-cadherin. The islands coincide, at least in part, with the isochronic cell clusters, as shown by pulse-labeling with bromodeoxyuridine. Likewise, isochronic clusters of the hyperstriatum ventrale relate to patchy heterogeneities in the cadherin-7 immunoreactivity pattern. Cadherins are known to mediate the aggregation and sorting of cells during development in many organs. Thei...Continue Reading

References

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Citations

Aug 4, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joanna J Rowell, Clifton W Ragsdale
Jan 4, 2007·International Journal of Biological Sciences·Kenneth D Cronin, Anthony A Capehart
Apr 3, 2008·The Journal of Comparative Neurology·Nicole HertelChristoph Redies
May 18, 2012·The Journal of Comparative Neurology·Nicole HertelLoreta Medina
Jan 2, 2003·The Journal of Comparative Neurology·Dragica Kovjanic, Christoph Redies
Apr 8, 2015·Journal of Neuroendocrinology·G M Coughlin, D M Kurrasch
Apr 9, 2015·Frontiers in Neuroanatomy·Nora-Emöke SzabóGonzalo Alvarez-Bolado

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