Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice

Brain Research
Li-Li WeiGeorge Liu

Abstract

Almost all of the candidate drugs for ischemic stroke failed to be translated from bench to beside. One important reason is that animals used in experimental studies cannot mimic ischemic patients due to lack of comorbidities like hypertension, diabetes and obesity. Therefore, it is better to test candidate drugs not only in normal animals but also in animals with comorbidities. Patchouli alcohol (PA), a natural tricyclic sesquiterpene in the traditional Chinese herb Pogostemonisherba, is well recognized for its anti-inflammation function in various inflammatory diseases. And as inflammation plays a very important role in cerebral ischemia/reperfusion (I/R) injury process and determines the ultimate brain damage, we hypothesized that PA could protect against cerebral I/R injury through its anti-inflammation ability. In this study, the effects of PA on cerebral I/R injury were evaluated in normal mice and obese mice. In normal mice with cerebral I/R injury, PA treatment reduced the infarct volume and neurological deficits in a dose- and time-dependent manner. PA treatment alleviated BBB dysfunction, inhibited mRNA and protein levels of TNF-α and IL-1β and modulated the activation of MAPKs signaling pathways. Moreover, PA also re...Continue Reading

Citations

May 28, 2019·International Journal of Molecular Sciences·Carmen Infante-Garcia, Monica Garcia-Alloza
Oct 12, 2020·International Immunopharmacology·Hee-Seop LeeSeong-Ho Lee
May 20, 2021·Oxidative Medicine and Cellular Longevity·Hui XuMingfu Wang
Oct 1, 2020·Pharmacology & Therapeutics·Tao TaoJohn H Zhang

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