Patchy gold coated Fe3 O4 nanospheres with enhanced catalytic activity applied for paper-based bipolar electrode-electrochemiluminescence aptasensors

Biosensors & Bioelectronics
Xin ZhangShou-Nian Ding

Abstract

In this work, novel multifunctional patchy gold coated Fe3O4 hybrid nanoparticles (PG-Fe3O4 NPs) have been successfully synthesized in aqueous medium via a facile adsorption-reduction method. A rational formation mechanism has been proposed by monitoring the morphological evolution. The PG-Fe3O4 NPs retained the good magnetic property and exhibited excellent catalytical effeciency towards the electrochemical reduction of hydrogen peroxide. Chronoamperometric and amperometric experiments indicated a relatively high catalytic rate constant of 3.13 × 105 M-1 s-1, a high sensitivity of 578.87 µA mM-1 cm-2 and a low Michaelis-Menten constant of 462 µM. Meanwhile, the introduction of patchy gold could help biofunctionalization via Au-S bond for different biodetection and biosensing purposes. Here, as an example, thiol-terminated aptamers were immobilized onto the patchy gold part as a signal probe to detect carcinoembryonic antigen (CEA). A related paper-based bipolar electrode-electrochemiluminescence (pBPE-ECL) aptasensor was fabricated as the low-cost, disposable and miniature platform. To improve the sensitivity, Au nanodendrites were electrodeposited at the BPE cathode as the matrix for Apt1 immobilization. This aptasensor showe...Continue Reading

Citations

Jan 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rudi LiuYingfu Li
Feb 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fengren WuBangshang Zhu
Oct 7, 2020·Biosensors & Bioelectronics·Tao MingXinxia Cai
Mar 14, 2021·Analytical and Bioanalytical Chemistry·Wei ZhengDaxiang Cui
Apr 6, 2021·Advances in Colloid and Interface Science·Ashis TripathyFilipe Samuel Silva
Apr 21, 2021·Expert Review of Molecular Diagnostics·Rajesh AhirwarSaroj Kumar
Jun 15, 2021·Chemical Reviews·Eka NovianaCharles S Henry
May 5, 2021·Annual Review of Analytical Chemistry·Laurent BouffierAlexander Kuhn
Nov 25, 2020·Analytical Chemistry·Kira L Rahn, Robbyn K Anand

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