Patency of cerebral microvessels after focal embolic stroke in the rat

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
C X WangA Shuaib

Abstract

In patients with thrombotic stroke, the occluded artery often reopens over time. This results through a natural dissolution of the occluding material, and fragments of the material may move downstream to obstruct distal arteries. The current study was undertaken to investigate the patency of brain microvessels at varying time intervals after injection of a preformed clot into the right internal carotid artery of rats. Cerebral microvessels in brain sections were visualized using immunohistochemistry for fibronectin (detecting existing microvessels) and Evans blue (visualizing perfused microvessels). The percentage of patent microvessels was calculated as the number of Evans blue-positive microvessels divided by the number of fibronectin-positive microvessels. In normal control animals, results showed that 98% +/- 3% (mean +/- SD) of microvessels in the cortex and 94% +/- 14% in the striatum were patent. In the ischemic animals, immediately after clot injection, microvessels in the cortex and striatum were occluded, mainly in the territory irrigated by the middle cerebral artery. One hour after clot injection, microvessels had reopened in most of the cortex but remained occluded in some portions of the striatum, possibly as a re...Continue Reading

References

Nov 1, 1992·Acta Neurologica Scandinavica·N HeyeJ Cervos-Navarro
Feb 1, 1990·Circulation Research·U GöbelW Kuschinsky
Mar 1, 1989·AJR. American Journal of Roentgenology·B C LeeE M Bradbury
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Jan 1, 1985·Stroke; a Journal of Cerebral Circulation·D KanekoT Ogawa
Jul 1, 1982·The Anatomical Record·P Coyle, P T Jokelainen
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K OvergaardG Boysen
Feb 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z ZhangM Chopp
Apr 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E BuschK A Hossmann
Aug 21, 1965·Lancet·P M DALALR R AIYAR

❮ Previous
Next ❯

Citations

Jan 30, 2004·Neuroscience Letters·Alireza P- ShabanzadehChen Xu Wang
Aug 22, 2001·Journal of Neuroscience Methods·C X WangA Shuaib
Jul 20, 2002·Progress in Neurobiology·Chen Xu Wang, Ashfaq Shuaib
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·S Thomas Carmichael
Oct 16, 2004·Journal of Neurosurgery·Fatima A SehbaJoshua B Bederson
Sep 2, 2008·Journal of Neurosurgery·Alireza P ShabanzadehChen Xu Wang
Dec 19, 2013·Translational Stroke Research·Saema AnsarStephen Meairs
Mar 15, 2005·Archives of Physiology and Biochemistry·M C PilatouW Steenbergen
Oct 11, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Turgay Dalkara, Ethem Murat Arsava
Jan 30, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Susanne SiemonsenJens Fiehler
Sep 4, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nils HenningerMarc Fisher
Jun 3, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Glenn A ArmitageIan R Winship
Oct 24, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yu-Ming ChuangChing-Po Lin
May 1, 2007·Experimental Neurology·Samer AldandashiAshfaq Shuaib
Mar 26, 2014·Journal of Neurochemistry·Mireia Campos-MartorellJoan Montaner
Apr 13, 2005·Brain Research·Alireza P ShabanzadehChen Xu Wang
Jun 9, 2006·Neurological Research·Fatima A Sehba, Joshua B Bederson
May 20, 2008·Journal of Vascular Surgery·Joseph H RappXian Mang Pan
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ashfaq ShuaibTao Yang
Aug 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gregory J del Zoppo, Takuma Mabuchi
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tatsuro MoriEng H Lo
Dec 5, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mark J R J BoutsRick M Dijkhuizen
Mar 23, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nils HenningerMarc Fisher
Aug 19, 2007·Stroke; a Journal of Cerebral Circulation·Cyrille OrsetDenis Vivien
Jul 26, 2003·Stroke; a Journal of Cerebral Circulation·David S Liebeskind
Jan 7, 2004·Stroke; a Journal of Cerebral Circulation·Carlos A MolinaJosé Alvarez-Sabín
Apr 25, 2009·Stroke; a Journal of Cerebral Circulation·Emma L BaileyJoanna M Wardlaw
Feb 12, 2005·Stroke; a Journal of Cerebral Circulation·Raza NoorAshfaq Shuaib
Apr 2, 2016·Stroke; a Journal of Cerebral Circulation·Cyrille OrsetDenis Vivien
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Chen Xu WangAshfaq Shuaib
Feb 3, 2007·European Neurology·Yu-Ming ChuangChing-Po Lin
Aug 2, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thorbjørn S EngedalLeif Østergaard
Jul 28, 2016·Journal of Neuroscience Research·Doodipala Samba ReddyFarida Sohrabji
Aug 23, 2007·ILAR Journal·Jeffrey A KleimDeAnna L Adkins

❮ Previous
Next ❯

Software Mentioned

Image
Pro Plus

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.