PMID: 11332173May 3, 2001Paper

Patent ductus arteriosus and cystic periventricular leucomalacia in preterm infants

Acta Paediatrica
P PladysP Bétrémieux

Abstract

To test the association between early disturbances in hemodynamics induced by left-to-right shunting through the duct and cystic periventricular leucomalacia. Forty-six preterm infants (27-32 wk) admitted to the neonatal intensive care unit with risk criteria. Patent ductus arteriosus was evaluated on days 1 and 4, and was significant (sPDA) in cases of absent or reversed end diastolic flow in the subductal aorta. Resistance index was measured in the anterior cerebral artery and in the subductal aorta. Diagnosis of cystic periventricular leucomalacia between day 10 and day 50. The 12 infants who developed cystic periventricular leucomalacia were compared with those who did not. On day 1, sPDA was more frequent (64% vs 26%; p = 0.03) in the cystic periventricular leucomalacia group, left ventricular output was higher (median = 341 vs 279 ml kg-1.min-1; p = 0.005), and rescue surfactant was more frequently used (83% vs 47%; p = 0.03). This latter association was confirmed by multivariate analysis. Resistance index in the anterior cerebral artery was increased in cases of significant patent ductus arteriosus (p < 0.01) and was correlated with resistance index in the subductal aorta. On day 1 in this selected population, sPDA has a...Continue Reading

Citations

Jun 6, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nilufer GuzogluUgur Dilmen
Nov 21, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Isabelle MercantiUmberto Simeoni
Jun 19, 2012·Pediatric Neurology·Tokio SugiuraHajime Togari
Jan 10, 2012·The Journal of Pediatrics·Valerie Y ChockKrisa P Van Meurs
Oct 23, 2009·The Journal of Pediatrics·Stephan HiedlOrsolya Genzel-Boroviczeny
Mar 12, 2016·Journal of Tropical Pediatrics·Kalyan Chakravarthy BallaKiron Varghese
Jun 5, 2004·Early Human Development·Claudio De FeliceGiuseppe Latini

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