Patent foramen ovale and cryptogenic stroke: diagnosis and updates in secondary stroke prevention.

Stroke and Vascular Neurology
Kristy Yuan, Scott Eric Kasner

Abstract

The patent foramen ovale (PFO), given its high prevalence in the general population and especially in patients with cryptogenic stroke, has long generated investigation and debate on its propensity for stroke by paradoxical embolism and its management for stroke prevention. The pendulum has swung for percutaneous PFO closure for secondary stroke prevention in cryptogenic stroke. Based on a review of current evidence, the benefit from PFO closure relies on careful patient selection: those under the age of 60 years with few to no vascular risk factors and embolic-appearing stroke deemed cryptogenic after thorough evaluation. As these data look towards influencing guideline statements and device approvals in the future, patient selection remains the crucial ingredient for clinical decision making and future trials.

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Citations

Mar 7, 2020·Stroke; a Journal of Cerebral Circulation·Mayank GoyalJohanna M Ospel
Nov 27, 2018·Journal of Surgical Case Reports·Christopher ElmsMary Kimbrough
Jan 30, 2021·Semergen·C Martín MañeroE Martín Rioboó
Mar 7, 2021·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Amr MansourMaiy H Elsayed
Jun 3, 2021·Journal of Cardiovascular Development and Disease·Veronica RomanoDaria Nurzynska
Jun 20, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Georg PunzengruberRonald K Binder
Aug 15, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Mateusz K HołdaDariusz Dudek

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Methods Mentioned

BETA
sedation

Software Mentioned

RESPECT
REDUCE
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