Patent Review (2017-2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases

Antioxidants
Dionysios V ChartoumpekisGerasimos P Sykiotis

Abstract

Research on the antioxidant pathway comprising the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and its cytoplasmic inhibitor Kelch-like ECH-associated protein 1 (Keap1) is ever increasing. As modulators of this pathway have started to be used in clinical trials and clinical practice, Nrf2 has become the subject of several patents. To assess the patent landscape of the last three years on Nrf2 and evaluate the main fields they refer to, we used the web-based tool PatSeer Pro to identify patents mentioning the Nrf2 pathway between January 2017 and May 2020. This search resulted in 509 unique patents that focus on topics such as autoimmune, neurodegenerative, liver, kidney, and lung diseases and refer to modulators (mainly activators) of the Nrf2 pathway as potential treatments. Autoimmunity emerged as the main theme among the topics of Nrf2 patents, including a broad range of diseases, such as systemic sclerosis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, Hashimoto's thyroiditis, etc.; however, there was a dearth of experimental support for the respective patents' claims. Given that chronic inflammation is the main element of the pathophysiology of most autoimmune di...Continue Reading

References

Sep 29, 2001·Kidney International·K YohS Takahashi
Jun 3, 2004·Physiological Genomics·Jiang LiJeffrey A Johnson
Nov 19, 2005·Biochemical and Biophysical Research Communications·Hiromi OkawaMasayuki Yamamoto
Apr 7, 2007·American Journal of Respiratory Cell and Molecular Biology·Narsa M ReddySekhar P Reddy
Jan 16, 2008·Developmental Cell·Gerasimos P Sykiotis, Dirk Bohmann
Apr 18, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·William O OsburnThomas W Kensler
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thomas E SussanShyam Biswal
Nov 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Delinda A JohnsonJeffrey A Johnson
Mar 20, 2010·Respiratory Research·Norihiro KikuchiNobuyuki Hizawa
Mar 4, 2011·Archives of Toxicology·Stephen L Slocum, Thomas W Kensler
Mar 17, 2011·Antioxidants & Redox Signaling·Nuria MaicasMaria José Alcaraz
Jun 11, 2011·American Journal of Respiratory Cell and Molecular Biology·Narsa M ReddySekhar P Reddy
Jun 2, 2012·Frontiers in Neurology·Zoe Fonseca-KellyKenneth S Shindler
Jun 30, 2012·Recent Patents on CNS Drug Discovery·Gururaj Joshi, Jeffrey A Johnson
Jul 4, 2012·Topics in Current Chemistry·Thomas W KenslerPaul Talalay
Aug 21, 2012·Nutrition Research·Jayesh Kumar BhattMoola Joghee Nanjan
Sep 21, 2012·The New England Journal of Medicine·Ralf GoldUNKNOWN DEFINE Study Investigators
Feb 1, 2013·Current Diabetes Reviews·Dionysios V Chartoumpekis, Thomas W Kensler
Mar 30, 2013·Biochemical and Biophysical Research Communications·Tae Gen SonSimonetta Camandola
Sep 12, 2013·Redox Biology·Emilia KansanenAnna-Liisa Levonen
Nov 12, 2013·The New England Journal of Medicine·Dick de ZeeuwUNKNOWN BEACON Trial Investigators
Feb 14, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yoichi MiyazakiTaiji Matsusaka
May 3, 2014·The New England Journal of Medicine·Dionysios V Chartoumpekis, Gerasimos P Sykiotis
May 8, 2014·The New England Journal of Medicine·Jonathan Himmelfarb, Katherine R Tuttle
May 7, 2015·Recent Patents on Endocrine, Metabolic & Immune Drug Discovery·Sonia M de FigueiredoRachel B Caligiorne
Aug 2, 2015·Free Radical Biology & Medicine·T Keith BlackwellMeltem Isik
Aug 19, 2015·Free Radical Biology & Medicine·Delinda A Johnson, Jeffrey A Johnson
Sep 13, 2015·Neurology·R Scott TurnerUNKNOWN Alzheimer's Disease Cooperative Study
Sep 13, 2015·European Journal of Medicinal Chemistry·Atul D JainTerry W Moore
Apr 14, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Keiko TaguchiMasayuki Yamamoto
May 24, 2016·Nature Communications·Eri H KobayashiMasayuki Yamamoto
Jun 18, 2016·Bioorganic & Medicinal Chemistry·Elango BhakkiyalakshmiKunka Mohanram Ramkumar

❮ Previous
Next ❯

Citations

Mar 12, 2021·Expert Review of Clinical Pharmacology·Melford Chuka EgbujorLuciano Saso
May 11, 2021·Frontiers in Immunology·Kim Ohl, Klaus Tenbrock
Jun 3, 2021·Antioxidants·Gerasimos P Sykiotis

❮ Previous
Next ❯

Software Mentioned

VizMap
Google Patents
PatSeer Pro

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Related Papers

Oxidative Medicine and Cellular Longevity
Qinmei LiuXinxin Ci
Oxidative Medicine and Cellular Longevity
Natalia Robledinos-AntónAntonio Cuadrado
The Journal of Nutritional Biochemistry
Ying HuangAh-Ng Tony Kong
© 2021 Meta ULC. All rights reserved