Paternal age and assisted reproductive technology: problem solver or trouble maker?

Panminerva Medica
Mariana Bertoncelli TanakaSandro C Esteves

Abstract

In our society, the number of couples with advanced reproductive age seeking fertility treatment is increasing steadily. While the negative effect of female age on assisted reproductive technology (ART) outcomes is well established, the impact of paternal age needs to be clarified. We reviewed the current literature to determine whether advanced paternal age affects the results of ART and the health of resulting offspring. We found that the published literature is overall supportive of a positive association between advanced paternal age (>40 years) and semen quality deterioration. However, the existing evidence does not corroborate nor discard the influence of advanced paternal age on ART outcomes. Similarly, the effect of paternal age on the health of ART offspring remains equivocal, although data from naturally-conceived children clearly indicates that advanced paternal age increases the frequency of genetic, neurodevelopmental, and psychiatric diseases in the progeny. Noteworthy, the current literature is limited and subjected to bias due to the impact of maternal age as a critical confounder. Health care providers should discuss with concerned couples the available options to counteract the possible negative influence of a...Continue Reading

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Citations

Apr 17, 2019·Panminerva Medica·Ashok AgarwalMatheus Roque
Apr 17, 2019·Panminerva Medica·Sandro C EstevesPeter Humaidan
Nov 10, 2020·Human Reproduction·Jolien Van OpstalAdelheid Soubry
Apr 1, 2021·Journal of Assisted Reproduction and Genetics·Bing SongYunxia Cao

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