Paternal centrosomal dynamics in early human development and infertility

Journal of Assisted Reproduction and Genetics
A H Sathananthan

Abstract

Our purpose was to demonstrate the dynamics of the human sperm centrosome during fertilization and cleavage. Human gametes, fertilized oocytes, and preimplantation embryos were examined by transmission electron microscopy. The functional sperm centrosome containing a typical centriole (proximal) is inherited at fertilization and forms a sperm monoaster. It then replicates and is perpetuated during cleavage. It organizes the mitotic apparatus at each stage of cleavage up to the hatching blastocyst stage. Bipolar spindles are formed in all monospermic and most dispermic embryos. Occasionally, two sperm asters and tripolar spindles are formed in dispermic embryos. Centrioles are associated with pronuclei and nuclei at interphases when they duplicate and occupy pivotal positions at spindle poles during mitoses. The maternal centrosome is not functional. The human embryo shows paternal centrosome inheritance and perpetuation like most other animals. Inheritance of defective centrosomes may lead to abnormal cleavage and contribute to infertility.

Citations

May 24, 2006·Microscopy Research and Technique·A Henry SathananthanAlan O Trounson
Jul 23, 2008·Molecular Reproduction and Development·Masahito TachibanaKunihiro Okamura
Apr 15, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Robert Milewski, Anna Ajduk
Dec 22, 2019·Animals : an Open Access Journal From MDPI·Barbara KijMonika Bugno-Poniewierska
Sep 30, 2006·Human Fertility : Journal of the British Fertility Society·Katie Feenan, Mary Herbert
May 17, 2000·Molecular Reproduction and Development·M MarinoB Dale
May 20, 2008·Journal of Experimental & Clinical Assisted Reproduction·Laszlo Nanassy, Douglas T Carrell
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Jan 4, 2021·Journal of Assisted Reproduction and Genetics·Swati PandruvadaTomer Avidor-Reiss
Oct 8, 2005·Fertility and Sterility·Masahito TachibanaKunihiro Okamura
Apr 17, 2008·Reproductive Biomedicine Online·Katerina ChatzimeletiouAlan H Handyside

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