PMID: 18418050Apr 18, 2008Paper

Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring

Cell Cycle
Jan TammingaOlga Kovalchuk

Abstract

It is now well accepted that parental whole body irradiation causes transgenerational genome and epigenome instability in the offspring. The majority of human exposures to radiation, such as therapeutic and diagnostic irradiation, are localized and focused. The potential of localized body-part exposures to affect the germline and thus induce deleterious changes in the progeny has not been studied. To investigate whether or not the paternal cranial irradiation can exert deleterious changes in the protected germline, we studied the accumulation of DNA damage in the shielded testes tissue. Here we report that the localized paternal cranial irradiation results in a significant accumulation of unrepaired DNA lesions in sperm cells and leads to a profound epigenetic dysregulation in the unexposed progeny conceived a week after paternal exposure.

Citations

May 12, 2011·Cancer Research·Olga A MartinWilliam M Bonner
Jul 17, 2012·Journal of Molecular Endocrinology·Abby F FleischAndrea A Baccarelli
Jul 26, 2011·Mutation Research·Yaroslav Ilnytskyy, Olga Kovalchuk
Jan 19, 2010·Mutation Research·Dietrich Averbeck
Dec 25, 2008·Environmental and Molecular Mutagenesis·Yaroslav IlnytskyyOlga Kovalchuk
Jun 8, 2012·Environmental and Molecular Mutagenesis·Yih-Horng ShiaoLucy M Anderson
Apr 19, 2013·International Journal of Radiation Biology·Charles KirkbyOlga Kovalchuk
Nov 10, 2009·International Journal of Radiation Biology·Carmel Mothersill, Colin Seymour
May 19, 2011·International Journal of Occupational Medicine and Environmental Health·Mohamed El-HelalyHend Shalaby
Jul 5, 2016·Frontiers in Behavioral Neuroscience·Anna KovalchukOlga Kovalchuk
Dec 17, 2016·International Journal of Molecular Sciences·Eva Yi KongKwan Ngok Yu
Apr 8, 2017·International Journal of Molecular Sciences·Xiaozeng LinDamu Tang
Dec 17, 2019·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·O V Shemetun, M A Pilinska
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Jul 28, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vivek Verma, Steven H Lin
May 1, 2021·International Journal of Molecular Sciences·Simonetta PazzagliaMariateresa Mancuso
Jun 5, 2021·Mutation Research. Reviews in Mutation Research· Swati, Vijayta D Chadha
Dec 7, 2021·Frontiers in Physiology·Ling GuoGui-Rong Ding

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