Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring

Breast Cancer Research : BCR
Raquel Santana da CruzSonia de Assis

Abstract

While many studies have shown that maternal factors in pregnancy affect the cancer risk for offspring, few studies have investigated the impact of paternal exposures on their progeny's risk of this disease. Population studies generally show a U-shaped association between birthweight and breast cancer risk, with both high and low birthweight increasing the risk compared with average birthweight. Here, we investigated whether paternal malnutrition would modulate the birthweight and later breast cancer risk of daughters. Male mice were fed AIN93G-based diets containing either 17.7% (control) or 8.9% (low-protein (LP)) energy from protein from 3 to 10 weeks of age. Males on either group were mated to females raised on a control diet. Female offspring from control and LP fathers were treated with 7,12-dimethylbenz[a]anthracene (DMBA) to initiate mammary carcinogenesis. Mature sperm from fathers and mammary tissue and tumors from female offspring were used for epigenetic and other molecular analyses. We found that paternal malnutrition reduces the birthweight of daughters and leads to epigenetic and metabolic reprogramming of their mammary tissue and tumors. Daughters of LP fathers have higher rates of mammary cancer, with tumors ari...Continue Reading

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Citations

Mar 14, 2019·Endocrine-related Cancer·Raquel Santana da CruzSonia de Assis
Aug 8, 2020·Frontiers in Nutrition·Raquel Santana da CruzSonia de Assis
Nov 29, 2020·BMC Biology·Joanna RutkowskaShinichi Nakagawa
Sep 27, 2019·Food Research International·Lívia Beatriz Aparecida Ribeiro SilvaThomas Prates Ong
Aug 2, 2020·Molecular and Cellular Endocrinology·Emilie Le BlévecChristophe Arnoult
Aug 28, 2021·Nutrients·Pauline DimofskiBrigitte Leininger-Muller

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Methods Mentioned

BETA
RNA-seq
PCR
MBD-seq

Software Mentioned

Quantity
blastn
ImageJ
one
AISAIC
ingenuity pathway analysis ( IPA )
Trimmomatic
Illumina
TargetScan

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