Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Kidney & Blood Pressure Research
Xiao Li ZhangBerthold Hocher

Abstract

Paternal exposure to adverse environmental conditions can act on offspring's phenotype and influence offspring's later life disease risk. Our study was designed to examine the effect of feeding male rats before mating a high-fat, high-sucrose and high-salt diet (HFSSD) over two generations (F0 and F1) on their offspring's (F2) liver function and gut microbiome composition. Male F0 rats and male F1 rats were fed either control diet or HFSSD before mating. Liver function of F2 offspring was investigated, and their gut microbiome composition was analyzed by 16S rRNA gene sequencing in the F2 offspring of rats whose fathers and grandfathers were fed with control diet (CD) (F0CD+F1CD-F2 group) or HFSSD prior to mating (F0HD+F1HD-F2 group). F2 offspring had higher serum aspartate aminotransferase activity (female, p < 0.05 and male, p < 0.01 respectively) compared with control. Shannon indexes of gut microbiota indicated a significantly higher diversity in the female F0HD+F1HD-F2 as compared to F0CD+F1CD-F2 female offspring (p < 0.01). The dominant phyla of all the groups were Bacteroidetes, Firmicutes and Proteobacteria. There were significant differences in gut bacterial community composition at phyla and genus level between the F0...Continue Reading

References

Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Jul 15, 1995·BMJ : British Medical Journal·D J Barker
Jan 11, 2005·Journal of the American College of Nutrition·D J P Barker
Oct 10, 2008·The American Journal of Clinical Nutrition·Maria Carmen ColladoSeppo Salminen
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Aug 7, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathleen C PageEndla K Anday
Oct 10, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kimberley D BruceChristopher D Byrne
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Jian LiBerthold Hocher
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Aug 25, 2012·Frontiers in Cellular and Infection Microbiology·Noora OttmanClara Belzer
Jan 5, 2013·Journal of Pediatric Gastroenterology and Nutrition·Pietro VajroAlessio Fasano
Feb 7, 2013·Trends in Neurosciences·Jane A Foster, Karen-Anne McVey Neufeld
Aug 1, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Paula J Brunton
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Dec 24, 2013·The Permanente Journal·Vishal SharmaSourabh Aggarwal
May 17, 2014·Gut·Herbert Tilg, Alexander R Moschen
Oct 11, 2014·Annals of Nutrition & Metabolism·Nicole O McPhersonMichelle Lane
Oct 11, 2014·Kidney & Blood Pressure Research·Christoph ReichetzederBerthold Hocher
Nov 18, 2014·World Journal of Gastroenterology : WJG·Giulia PaolellaPietro Vajro
Dec 17, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G L Rodríguez-GonzálezE Zambrano
Feb 17, 2015·World Journal of Gastroenterology : WJG·Masami Minemura, Yukihiro Shimizu
Nov 12, 2015·World Journal of Gastroenterology : WJG·Makoto UsamiHayato Yamashita
Nov 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jérôme BoursierAnna Mae Diehl
Jan 15, 2016·Nature·Erica D SonnenburgJustin L Sonnenburg
May 14, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Berthold HocherElke Schaeffeler
Jul 28, 2016·Journal of Hypertension·Jian LiBerthold Hocher

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Citations

Nov 29, 2020·BMC Biology·Joanna RutkowskaShinichi Nakagawa
May 5, 2021·Trends in Endocrinology and Metabolism : TEM·Carina BoddenAmy C Reichelt
Oct 2, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Hamza AnwerMalgorzata Lagisz

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