Paternity change and the recurrence risk in familial hypertensive disorder in pregnancy

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Sigrun HjartardottirValgerdur Steinthorsdottir

Abstract

To investigate if there is an increased risk for recurrence of hypertensive disorder in pregnancy with a new partner and whether this is affected by maternal age and the interbirth interval through use of familial material. Data on 614 multiparous women, with confirmed de novo hypertensive disorder in a first pregnancy, were used to assess the effect of paternity and interbirth interval on recurrence of hypertensive disorders. There were 121 women (19.7%) who had changed partner. Recurrent hypertension occurred in 318 women (64.5%) with the same partner and in 75 women (62%) with a new partner. The odds ratio (OR) for recurrence with the same partner was 1.115 (95% CI 0.739-1.680) and with a new partner 0.897 (95% CI 0.595-1.353). The mean interbirth interval was longer for women with recurrent hypertension (4.9 vs. 4.0 years, p = 0.0002). The OR for developing recurrent hypertensive disorder was 1.154 (95% CI 1.049-1.269) for every interval year with the same partner and 1.145 (95% CI 0.958-1.368) with a new partner after correction for maternal age. In women with a positive family history and previous hypertension in pregnancy, change of paternity does not influence the risk of recurrence. Increasing interbirth interval may a...Continue Reading

Citations

Jul 31, 2007·Paediatric and Perinatal Epidemiology·Jun Zhang, Geeta Patel
Sep 5, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G BandoliC D Chambers
Jun 20, 2017·Nature Genetics·Ralph McGinnisLinda Morgan
Mar 12, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Oladapo OlayemiBabatunde Salako
May 21, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Sonia Ananthakrishnan
Jan 28, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Simone SepLouis Peeters
Jul 27, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·T R EinarsonG Koren

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