Path-dependent connectivity, not modularity, consistently predicts controllability of structural brain networks

Network Neuroscience
Shubhankar P. PatankarDanielle S Bassett

Abstract

The human brain displays rich communication dynamics that are thought to be particularly well-reflected in its marked community structure. Yet, the precise relationship between community structure in structural brain networks and the communication dynamics that can emerge therefrom is not well understood. In addition to offering insight into the structure-function relationship of networked systems, such an understanding is a critical step toward the ability to manipulate the brain's large-scale dynamical activity in a targeted manner. We investigate the role of community structure in the controllability of structural brain networks. At the region level, we find that certain network measures of community structure are sometimes statistically correlated with measures of linear controllability. However, we then demonstrate that this relationship depends on the distribution of network edge weights. We highlight the complexity of the relationship between community structure and controllability by performing numerical simulations using canonical graph models with varying mesoscale architectures and edge weight distributions. Finally, we demonstrate that weighted subgraph centrality, a measure rooted in the graph spectrum, and which c...Continue Reading

References

Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·M Girvan, M E J Newman
Mar 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M E J Newman, M Girvan
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S Tuch
Feb 25, 2005·Nature·Roger Guimerà, Luís A Nunes Amaral
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ernesto Estrada, Juan A Rodríguez-Velázquez
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·M E J Newman
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M B Hastings
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher J HoneyOlaf Sporns
Jul 6, 2007·PloS One·Patric HagmannJean-Philippe Thiran
Jan 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin Rosvall, Carl T Bergstrom
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
May 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacob G FosterMaya Paczuski
Jun 29, 2010·Current Opinion in Neurology·Heidi Johansen-Berg
Dec 15, 2010·Frontiers in Neuroscience·David MeunierEdward T Bullmore
Apr 5, 2011·NeuroImage·Mikail Rubinov, Olaf Sporns
Apr 19, 2011·Trends in Cognitive Sciences·Danielle S Bassett, Michael S Gazzaniga
May 13, 2011·Nature·Yang-Yu LiuAlbert-László Barabási
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Mar 10, 2012·Journal of Cognitive Neuroscience·Caterina GrattonMark D'Esposito
Apr 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Petra E VértesEdward T Bullmore
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martijn P van den HeuvelOlaf Sporns
Jan 9, 2013·Current Opinion in Neurobiology·Olaf Sporns
Feb 28, 2013·Brain Connectivity·Petra RitterViktor K Jirsa
Mar 19, 2013·PloS One·Joaquín GoñiOlaf Sporns
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emma K TowlsonEdward T Bullmore
Nov 2, 2013·Science·Hae-Jeong Park, Karl Friston
Nov 16, 2013·Trends in Cognitive Sciences·Martijn P van den Heuvel, Olaf Sporns
Dec 19, 2013·PloS One·Fang-Cheng YehWen-Yih Isaac Tseng
Jun 18, 2015·Nature Reviews. Neuroscience·Gustavo DecoMorten L Kringelbach
Sep 24, 2015·Annual Review of Psychology·Olaf Sporns, Richard F Betzel
Oct 2, 2015·Nature Communications·Shi GuDanielle S Bassett
Dec 5, 2015·Scientific Reports·Zhongzhi ZhangYuhao Yi
Feb 13, 2016·Current Opinion in Neurobiology·Xiao-Jing Wang, Henry Kennedy
May 27, 2016·Nature Reviews. Neuroscience·Giulio TononiChristof Koch
Jul 30, 2016·Scientific Reports·Richard F BetzelDanielle S Bassett
Sep 10, 2016·PLoS Computational Biology·Sarah Feldt MuldoonDanielle S Bassett
Sep 23, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Danielle S Bassett, Edward T Bullmore

❮ Previous
Next ❯

Citations

Nov 17, 2020·Network Neuroscience·Daniel GrahamBratislav Mišić

❮ Previous
Next ❯

Software Mentioned

Brain Connectivity Toolbox

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.