Pathobiology of focal segmental glomerulosclerosis: new developments

Current Opinion in Nephrology and Hypertension
Vivette D D'Agati

Abstract

Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and renal failure. All forms of FSGS share podocyte injury and depletion as central mediators. This review focuses on new insights into pathogenesis from study of extrinsic toxins in experimental models, permeability factors in human disease, and novel genetic causes. Experimental toxin models have advanced our understanding of the threshold and dynamics of podocyte injury. Following initial podocyte depletion, spreading fields of podocyte injury through secondary mediators appear to be important in generating the segmental pathologic lesions. Proliferating glomerular epithelial cells are common in FSGS, although there are conflicting views about their identity. Evidence suggests potential contributions by mature parietal epithelial cells, facultative stem cells and podocytes. A number of novel candidate permeability factors that affect podocyte function and motility have been discovered in human FSGS and related podocytopathy minimal change disease. Exome capture has identified new monogenic causes of familial FSGS. Apolipoprotein L-1 (APOL1) is expressed in podocytes, and the prevalence of APOL1 risk alleles in patients of African descent with pr...Continue Reading

References

Oct 3, 1999·Journal of the American Society of Nephrology : JASN·E DenamurP M Ronco
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N KambhamV D D'Agati
Oct 24, 2000·Kidney International·L M DolerisJ Bariety
May 17, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S J McTaggartC L Jones
Sep 11, 2001·The American Journal of Pathology·M SimonsH Holthöfer
Jan 12, 2002·The American Journal of Pathology·Séverine RoselliCorinne Antignac
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gian Marco GhiggeriCarlo L Balduini
Apr 22, 2003·Seminars in Nephrology·Chagriya KitiyakaraPaul Eggers
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Bruno GuéryDominique Chauveau
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vivette D D'AgatiJ Charles Jennette
May 18, 2004·The Journal of Clinical Investigation·Jochen ReiserPeter Mundel
Mar 11, 2005·Journal of the American Society of Nephrology : JASN·Taiji MatsusakaIekuni Ichikawa
Apr 12, 2005·Current Opinion in Nephrology and Hypertension·Iekuni IchikawaTaiji Matsusaka
May 10, 2005·American Journal of Medical Genetics. Part a·Thomas LückeAnibh M Das
Jul 1, 2005·Journal of the American Society of Nephrology : JASN·Takako AsanoTaiji Matsusaka
Aug 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Winston W BakkerJola J Kapojos
Jan 10, 2006·American Journal of Human Genetics·Catarina QuinziiMichio Hirano
May 20, 2006·Nature Reviews. Microbiology·Etienne PaysDavid Pérez-Morga
Mar 21, 2007·Pediatrics·Bernward G HinkesUNKNOWN Arbeitsgemeinschaft für Paediatrische Nephrologie Study Group
May 12, 2007·American Journal of Physiology. Renal Physiology·Diana M IglesiasPaul R Goodyer
Aug 24, 2007·Kidney International·M M LöwikL P van den Heuvel
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Francesca Diomedi-CamasseiFrancesco Emma
Dec 11, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rasheed GbadegesinFriedhelm Hildebrandt
Dec 18, 2007·Nature Medicine·Changli WeiJochen Reiser
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Aoife M WatersTino D Piscione
Apr 4, 2008·American Journal of Physiology. Renal Physiology·Avril A MorrisonMichael R Ladomery
Apr 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael Fischereder
Jun 3, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Virginia J SavinMukut Sharma
Aug 30, 2008·Journal of the American Society of Nephrology : JASN·Rachel LennonMoin A Saleem
Sep 17, 2008·Nature Genetics·Jeffrey B KoppCheryl A Winkler
Oct 18, 2008·Autophagy·Siqin ZhaorigetuChien-an A Hu
Nov 14, 2008·Journal of the American Society of Nephrology : JASN·Mira KrendelMark S Mooseker
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Elisa RonconiPaola Romagnani

❮ Previous
Next ❯

Citations

Jun 19, 2012·Current HIV/AIDS Reports·Jose M MiroJose M Gatell
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·Toshiyuki Imasawa, Rodrigue Rossignol
Jul 7, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christoph Schell, Tobias B Huber
Feb 6, 2014·PloS One·Annika Lindskog JonssonJenny Nyström
Jan 9, 2014·BMC Nephrology·Marijan SaragaMirna Saraga-Babić
Aug 27, 2014·Nature Reviews. Nephrology·Howard Trachtman, Jochen Reiser
Feb 7, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Louis-Philippe LaurinKaren E Weck
Apr 9, 2015·Clinical Kidney Journal·Nobuo TsuboiTakashi Yokoo
Apr 12, 2016·Frontiers in Pediatrics·Sarangarajan Ranganathan
Jun 7, 2016·Nature Reviews. Nephrology·Vivette D D'AgatiManuel Praga
Aug 30, 2014·Advances in Chronic Kidney Disease·Michael B Stokes, Vivette D D'Agati
Feb 4, 2014·Seminars in Nephrology·Björn HartlebenTobias B Huber
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sandra Amaral, Alicia Neu
May 18, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Magdalena PawlikPaweł P Jagodziński
Mar 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marco TucciFrancesco Silvestris
Sep 21, 2016·Scientific Reports·Fang ZhongNan Chen
Jul 22, 2016·American Journal of Physiology. Renal Physiology·Bairbre A McNicholasStuart J Shankland
Aug 23, 2018·The Nurse Practitioner·Angela Y Wong, Rita Marie John
Mar 1, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Avi Z Rosenberg, Jeffrey B Kopp
May 29, 2015·American Journal of Physiology. Renal Physiology·Mousa AbkhezrStuart E Dryer
Aug 8, 2015·Transplantation·Guillaume CanaudChristophe Legendre
Jan 1, 2014·International Scholarly Research Notices·Kristin MeliambroKirk N Campbell
Sep 28, 2017·BioMed Research International·Virginia J SavinEllen T McCarthy
Apr 15, 2016·American Journal of Physiology. Renal Physiology·Natalya V KaverinaStuart J Shankland
Dec 1, 2012·Clinical Kidney Journal·Peter W Mathieson
Dec 29, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alexander J Howie
Aug 17, 2019·Journal of the American Society of Nephrology : JASN·Louise K FarmerGavin I Welsh
Feb 24, 2021·Journal of Cell Communication and Signaling·Baichao SunGuangdong Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Nephrology and Hypertension
Vivette D D'Agati
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Marije LöwikLambert van den Heuvel
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Florian GrahammerTobias B Huber
Seminars in Nephrology
Takuji IshimotoRichard J Johnson
© 2022 Meta ULC. All rights reserved