Pathobiology of wound healing after glaucoma filtration surgery

BMC Ophthalmology
Osamu YamanakaPeter S Reinach

Abstract

Conjunctival and subconjunctival fibrogenesis and inflammation are sight compromising side effects that can occur subsequent to glaucoma filtration surgery. Despite initial declines in intraocular pressure resulting from increasing aqueous outflow, one of the activated responses includes marshalling of proinflammatory and pro-fibrogenic cytokine mediator entrance into the aqueous through a sclerostomy window and their release by local cells, as well as infiltrating activated immune cells. These changes induce dysregulated inflammation, edema and extracellular matrix remodeling, which occlude outflow facility. A number of therapeutic approaches are being taken to offset declines in outflow facility since the current procedure of inhibiting fibrosis with either mitomycin C (MMC) or 5-fluorouracil (5-FU) injection is nonselective. One of them entails developing a new strategy for reducing fibrosis induced by wound healing responses including myofibroblast transdifferentiation and extracellular matrix remodeling in tissue surrounding surgically created shunts. The success of this endeavor is predicated on having a good understanding of conjunctival wound healing pathobiology. In this review, we discuss the roles of inappropriately ...Continue Reading

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May 31, 2017·International Journal of Molecular Sciences·Hong JiYehong Zhuo
Sep 1, 2017·Journal of Glaucoma·Ricardo Y AbeVital P Costa
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Sep 16, 2020·Acta Ophthalmologica·Kevin GillmannKaweh Mansouri
Jul 6, 2021·Journal of Glaucoma·Serpil YazganOzhan Koc

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Methods Mentioned

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