Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows

Journal of Animal Science
Douglas D Bannerman

Abstract

Mastitis is a highly prevalent and costly disease of dairy cows that is commonly caused by intramammary bacterial infection. The innate immune response to bacterial penetration of the mammary gland is evoked within hours of infection, and the rapidity and magnitude of this response have been demonstrated to influence the resolution of this disease. Cytokines and other mediators of inflammation are known to play critical roles in the innate immune response to intramammary infection. The objectives of this review are to summarize the current understanding of the cytokine response to intramammary infection, highlight recent findings identifying differences in the cytokine response to various bacterial pathogens, and discuss future research directions that will increase our knowledge of the role of inflammatory mediators in predicting and governing the outcome of mastitis.

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Citations

Sep 6, 2011·Journal of Mammary Gland Biology and Neoplasia·Jamie L Boehmer
Oct 15, 2011·Journal of Mammary Gland Biology and Neoplasia·Gina M Pighetti, A A Elliott
Mar 27, 2013·Veterinary Immunology and Immunopathology·Kazuhiro KawaiNaoki Isobe
Jan 20, 2012·Journal of Proteome Research·Stine L BislevEmøke Bendixen
Jun 14, 2013·BMC Veterinary Research·Katarzyna Wojdak-MaksymiecTomasz Strabel
Jan 1, 2009·Irish Veterinary Journal·Rn Zadoks, Jl Fitzpatrick
Aug 27, 2010·The Journal of Nutrition·Joanne E ArsenaultEduardo Villamor
Jun 22, 2014·Molecular and Cellular Probes·Zhixiong LiXiaolin Liu
Apr 14, 2012·The Veterinary Journal·Olga Wellnitz, Rupert M Bruckmaier
Jul 30, 2015·BMC Veterinary Research·Isabel BauerHans-Martin Seyfert
Oct 24, 2014·Frontiers in Immunology·Kathleen Thompson-CrispiBonnie A Mallard
Oct 8, 2016·Frontiers in Immunology·Carl-Fredrik JohnzonGunnar Pejler
Jun 14, 2017·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Janet E WilliamsMichelle K McGuire
Oct 7, 2017·Transboundary and Emerging Diseases·P RainardJ R Middleton
Feb 3, 2016·Journal of Dairy Science·L M Sordillo
Feb 6, 2018·Journal of Dairy Science·Lorraine M Sordillo

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