Pathogen inactivation of platelets for transfusion.

Platelets
Joan Cid, Miquel Lozano

Abstract

Bacterial contamination of blood components is a recurrent topic in transfusion medicine community. This issue is even more important with platelet transfusions because of storage of platelet components at room temperature for 5 days. Pathogen inactivation methods are a proactive approach to deal with an infectious agent. All available methods use UV light, with or without a photosensitizer, to inactivate potential pathogens. As with other medical interventions, pathogen inactivation methods carry benefits and risks. Among benefits, inactivation of known and unknown transfusion-transmitted pathogens, inactivation of residual leukocytes, and increased storage length from 5 to 7 days are the most interesting. The main risk is the impact on clinical efficacy of pathogen-reduced platelets. After inactivation, pathogen-reduced platelets are associated with a lower number of platelets in the final product, lower 24-hour corrected count increment, and shorter transfusion interval when compared with non-inactivated platelets. However, eight of nine randomized controlled trials showed that transfusing pathogen-reduced platelets were not inferior to transfusing usual platelet components in the prevention of bleeding episodes. In conclusi...Continue Reading

References

May 29, 2010·British Journal of Haematology·Jean-Louis H KerkhoffsUNKNOWN Dutch - Belgian HOVON cooperative group
Nov 9, 2012·Vox Sanguinis·C V Prowse
Apr 17, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M Lozano, J Cid
Oct 10, 2013·Current Opinion in Hematology·Miguel Lozano, Joan Cid
Jul 22, 2014·Photochemistry and Photobiology·Janna M MundtRaymond P Goodrich
Apr 23, 2015·The New England Journal of Medicine·Edward L SnyderRichard J Benjamin
Feb 3, 2018·JAMA Oncology·Frédéric GarbanUNKNOWN Evaluation of the Efficacy of Platelets Treated With Pathogen Reduction Process (EFFIPAP) Study Group

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