Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells.

The Journal of Immunology : Official Journal of the American Association of Immunologists
S SadL Krishnan

Abstract

CD8+ T cell memory is critical for protection against many intracellular pathogens. However, it is not clear how pathogen virulence influences the development and function of CD8+ T cells. Salmonella typhimurium (ST) is an intracellular bacterium that causes rapid fatality in susceptible mice and chronic infection in resistant strains. We have constructed recombinant mutants of ST, expressing the same immunodominant Ag OVA, but defective in various key virulence genes. We show that the magnitude of CD8+ T cell response correlates directly to the intracellular proliferation of ST. Wild-type ST displayed efficient intracellular proliferation and induced increased numbers of OVA-specific CD8+ T cells upon infection in mice. In contrast, mutants with defective Salmonella pathogenicity island II genes displayed poor intracellular proliferation and induced reduced numbers of OVA-specific CD8+ T cells. However, when functionality of the CD8+ T cell response was measured, mutants of ST induced a more functional response compared with the wild-type ST. Infection with wild-type ST, in contrast to mutants defective in pathogenicity island II genes, induced the generation of mainly effector-memory CD8+ T cells that expressed little IL-2, f...Continue Reading

References

Jun 1, 1992·The Journal of Experimental Medicine·J T Harty, M J Bevan
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L FlynnB R Bloom
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K Y Leung, B B Finlay
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S I MillerJ J Mekalanos
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J E Galán, R Curtiss
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E A GroismanF Heffron
Sep 1, 1995·The Journal of Experimental Medicine·M J Bevan
Aug 19, 1995·Gene·N TakahashiM Hirose
Mar 1, 1993·Infection and Immunity·A D RobertsI M Orme
Jan 12, 1996·Science·R M Zinkernagel
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E SheaD W Holden
Jan 1, 1996·Annual Review of Immunology·B D Jones, S Falkow
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed
Apr 19, 2000·Journal of Leukocyte Biology·H W Mittrücker, S H Kaufmann
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·F NiedergangJ P Kraehenbuhl
Mar 10, 2001·Nature·R L ReinhardtM K Jenkins
Mar 10, 2001·Nature·P ChampagneG Pantaleo
Jul 14, 2001·Science·J Sprent, D F Tough
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J E Galán
Jan 5, 2002·Microbes and Infection·S H KaufmannB B Finlay
May 11, 2002·Nature Reviews. Immunology·Susan M KaechRaft Ahmed
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Feb 4, 2003·Nature Immunology·E John WherryRafi Ahmed
Apr 10, 2004·Science·Pascale Cossart, Philippe J Sansonetti
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henk van FaassenSubash Sad
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel A LuuSubash Sad

❮ Previous
Next ❯

Citations

Aug 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Homam AlbaghdadiSubash Sad
Feb 1, 2014·Lab on a Chip·Lang NanXueyong Wei
Mar 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiki TakamuraMasaaki Miyazawa
Mar 13, 2020·Biomicrofluidics·Cheuk Wang FungAngela Ruohao Wu
Dec 9, 2014·Frontiers in Immunology·Marcela Lopez-MedinaVianney Ortiz-Navarrete
Feb 26, 2011·Immunological Reviews·Jonathan JantschMichael Hensel
Dec 19, 2012·Cell Host & Microbe·Amy L KullasAdrianus W M van der Velden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.