Pathogen recognition or homeostasis? APC receptor functions in innate immunity

Comptes rendus biologies
Siamon Gordon

Abstract

Myeloid cells (macrophages, neutrophils, dendritic cells) express a repertoire of plasma membrane receptors able to recognize all classes of macromolecules. The concept of pattern recognition has emphasized microbial ligands and host defence. However, these receptors play a broader role in tissue homeostasis within multicellular hosts, clearing the extracellular environment of potential undesirable ligands arising endogenously as well as from without. This article will evaluate one of the paradigms that underlie innate immunity.

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Citations

Oct 24, 2007·Scandinavian Journal of Immunology·J Cunliffe
Jun 27, 2013·Infection and Immunity·Sandra Bonne-AnnéeDavid Abraham
Feb 7, 2013·BMC Immunology·Changqi WangDavid Ch Harris
Oct 18, 2005·Pharmacology & Therapeutics·Angela Haczku
Apr 19, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nadia Danilova
May 7, 2008·Biomedical Materials·Zhidao Xia, James T Triffitt
Aug 9, 2005·Clinical and Diagnostic Laboratory Immunology·Agostino PuglieseDonato Torre

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