Pathogen reduction technologies: The pros and cons for platelet transfusion

Platelets
Audrey MagronEric Boilard

Abstract

The transfusion of platelets is essential for diverse pathological conditions associated with thrombocytopenia or platelet disorders. To maintain optimal platelet quality and functions, platelets are stored as platelet concentrates (PCs) at room temperature under continuous agitation-conditions that are permissive for microbial proliferation. In order to reduce these contaminants, pathogen reduction technologies (PRTs) were developed by the pharmaceutical industry and subsequently implemented by blood banks. PRTs rely on chemically induced cross-linking and inactivation of nucleic acids. These technologies were initially introduced for the treatment of plasma and, more recently, for PCs given the absence of a nucleus in platelets. Several studies verified the effectiveness of PRTs to inactivate a broad array of bacteria, viruses, and parasites. However, the safety of PRT-treated platelets has been questioned in other studies, which focused on the impact of PRTs on platelet quality and functions. In this article, we review the literature regarding PRTs, and present the advantages and disadvantages related to their application in platelet transfusion medicine.

References

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Citations

Mar 23, 2018·Platelets·Marie Lordkipanidzé
Apr 6, 2019·Transfusion·Stephen J Wagner, Todd M Getz
Apr 9, 2020·Frontiers in Cardiovascular Medicine·Idrissa DialloPatrick Provost
Jun 21, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nicolas MalvauxMarcia Cardoso
Aug 31, 2021·Platelets·Norman F LucAnirban Sen Gupta

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