Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review

Journal of Clinical Medicine
Anna KoumarianouKosmas Daskalakis

Abstract

Mesenteric fibrosis (MF) constitutes an underrecognized sequela in patients with small intestinal neuroendocrine neoplasms (SI-NENs), often complicating the disease clinical course. The aim of the present systematic review, carried out by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, is to provide an update in evolving aspects of MF pathogenesis and its clinical management in SI-NENs. Complex and dynamic interactions are present in the microenvironment of tumor deposits in the mesentery. Serotonin, as well as the signaling pathways of certain growth factors play a pivotal, yet not fully elucidated role in the pathogenesis of MF. Clinically, MF often results in significant morbidity by causing either acute complications, such as intestinal obstruction and/or acute ischemia or more chronic conditions involving abdominal pain, venous stasis, malabsorption and malnutrition. Surgical resection in patients with locoregional disease only or symptomatic distant stage disease, as well as palliative minimally invasive interventions in advanced inoperable cases seem clinically meaningful, whereas currently available systemic and/or targeted treatments do not unequivocally affect the development o...Continue Reading

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Citations

Aug 6, 2020·Journal of Clinical Medicine·Sara PuscedduFilippo de Braud
Jan 16, 2021·Journal of Clinical Medicine·Francesco Panzuto
Apr 3, 2021·World Journal of Gastrointestinal Surgery·Cornelius J FernandezJoseph M Pappachan
May 4, 2021·Frontiers in Endocrinology·Giovanni VitaleAnnamaria Colao

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Methods Mentioned

BETA
biopsy
surgical resection
prophylactic surgery

Software Mentioned

TELECAST
TELESTAR

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