Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back

Clinical and Translational Allergy
Rik SchrijversPascal Demoly

Abstract

Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions themselves but also by the use of alternatives which are sometimes less effective or even more dangerous. Diagnostic procedures rely on clinical history, skin testing and potential provocation testing, whereas validated in vitro diagnostic procedures are still lacking for most of them. Recent work in the field of pharmacogenomics combined with basic scientific research has provided insights in the pathogenesis of abacavir and carbamazepine hypersensitivities linked with certain human leucocyte antigen risk alleles. Nevertheless, important scientific questions on how other DHR arise and how host-drug interactions occur, remain unanswered. Recent work indicates an intricate relation between host, drug and pathogens in severe cutaneous and systemic reactions and provides more insights in the role of regulatory T-cells and viral reactivation in these reactions. In this review we focus on type IV delayed-type DHR, and a...Continue Reading

References

Jan 1, 1994·Annual Review of Immunology·P Matzinger
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·R S Gruchalla
Feb 16, 2002·Contact Dermatitis·A BarbaudUNKNOWN European Society of Contact Dermatitis
Apr 16, 2002·Science·Polly Matzinger
Dec 31, 2002·Toxicology·Munir PirmohamedB Kevin Park
Jun 6, 2003·The British Journal of Dermatology·V DescampsB Crickx
Oct 22, 2003·Annals of Internal Medicine·Werner J Pichler
Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Andreas BeelerWerner J Pichler
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Tetsuo ShioharaYoko Kano
Jul 17, 2007·The Journal of Antimicrobial Chemotherapy·Hsin-Yun SunShan-Chwen Chang
Aug 19, 2007·The Journal of Allergy and Clinical Immunology·Chih-Wen Ou YangYuan-Tsong Chen
Feb 8, 2008·The New England Journal of Medicine·Simon MallalUNKNOWN PREDICT-1 Study Team
Jan 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wan Beom ParkKang Won Choe
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryo TakahashiTetsuo Shiohara
Jun 12, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Francesco BroccoloMauro S Malnati
Dec 19, 2009·Handbook of Experimental Pharmacology·Jinze Li, Jack P Uetrecht
Aug 27, 2010·Science Translational Medicine·Damien PicardPhilippe Musette
Feb 23, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G PorebskiW J Pichler
Mar 5, 2011·The Journal of Allergy and Clinical Immunology·Elizabeth J PhillipsSimon A Mallal
Apr 13, 2011·British Journal of Clinical Pharmacology·Jacqueline AdamDaniel Yerly
May 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul WhitakerB Kevin Park
Sep 20, 2011·The Journal of Allergy and Clinical Immunology·Tai-Ming KoShuen-Iu Hung
Oct 25, 2011·Annual Review of Pharmacology and Toxicology·Mandvi BharadwajJames McCluskey
Mar 1, 2012·The Journal of Pharmacology and Experimental Therapeutics·Sabah El-GhaieshDean J Naisbitt
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·David A OstrovBjoern Peters
Jun 23, 2012·Nature·Patricia T IllingJames McCluskey
Jun 26, 2012·Current Opinion in Allergy and Clinical Immunology·Paul WhitakerDaniel Peckham
Oct 3, 2012·The Medical Journal of Australia·Damian J HardingDavid Nolan
Oct 31, 2012·The British Journal of Dermatology·M E PolakM R Ardern-Jones
Apr 17, 2013·Clinical Pharmacology and Therapeutics·U AmstutzUNKNOWN CPNDS Consortium
Apr 23, 2013·Journal of the American Academy of Dermatology·Zain HusainRobert A Schwartz
May 28, 2013·The Journal of Allergy and Clinical Immunology·Benno SchnyderWerner J Pichler
Aug 21, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G PorebskiW J Pichler
Oct 25, 2013·The New England Journal of Medicine·F-R ZhangJ-J Liu
Feb 15, 2014·International Archives of Allergy and Immunology·Yuttana Srinoulprasert, Werner J Pichler
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Rebecca PavlosElizabeth Phillips

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Citations

Apr 7, 2017·Current Allergy and Asthma Reports·Antonino RomanoFrancesco Gaeta
Nov 1, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F DragoA Parodi
Dec 20, 2017·Frontiers in Medicine·Philippe Musette, Baptiste Janela
Mar 4, 2017·The British Journal of Dermatology·N R AdlerE J Phillips
Apr 27, 2019·The British Journal of Ophthalmology·Gurumurthy SrividyaShweta Agarwal
Jan 7, 2017·The Journal of Biological Chemistry·Atiye ToksoyMarc Schmidt
Feb 6, 2018·The Journal of Clinical Investigation·Chuang-Wei WangUNKNOWN the Taiwan Severe Cutaneous Adverse Reaction (TSCAR) Consortium
May 12, 2018·International Journal of Molecular Medicine·Pascal IckrathStephan Hackenberg
Mar 23, 2018·Molecular Diagnosis & Therapy·Kalliopi GerogianniKonstantinos Dimas
Jul 12, 2017·Immunogenetics·Patricia T IllingJames McCluskey
May 16, 2019·Asia Pacific Allergy·Anthea AnantharajahWinnie Tong
Sep 30, 2020·Allergy·Adriana ArizaTahia D Fernandez
Nov 13, 2020·Asia Pacific Allergy·Yuttana SrinoulprasertDuangjit Kanistanon
Mar 23, 2021·Journal of Immunological Methods·Bernhardt SachsAndreas Glässner
Jan 18, 2018·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Eman Y Abu-RishYasser Bustanji
Jun 8, 2021·Seminars in Immunopathology·Susanne Radonjic-HoesliDagmar Simon
May 22, 2021·Frontiers in Immunology·Patompong SatapornpongChonlaphat Sukasem
Sep 3, 2021·International Journal of Clinical Practice·Violeta KvedarieneAlgirdas Edvardas Tamosiunas

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Methods Mentioned

BETA
enzyme-linked immunosorbent

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