PMID: 6408297Mar 15, 1983Paper

Pathogenesis and immunotherapy of insulin-dependent (type I) diabetes mellitus

Klinische Wochenschrift
J Bertrams

Abstract

The association of insulin-dependent (type I) diabetes mellitus with HLA-DR3 and DR4 and with several epidemiological, virological, immunological, and clinical data suggests a heterogenous pathogenesis. the initial lesion in most cases is a virologically induced autoimmune process. It is only rarely that insulin-dependent diabetes results from a pure viral infection or as part of polyendocrine autoimmune deficiencies. The knowledge of the genetical risk factors and of disease-specific humoral and cellular immune deviations exhibits possibilities of successful intervention by means of immunotherapy.

References

Oct 9, 1976·Lancet·G F Bottazzo, D Doniach
Sep 1, 1978·Tissue Antigens·N R FaridW H Marshall
Nov 8, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
May 24, 1979·The New England Journal of Medicine·J W YoonA L Notkins
Nov 1, 1979·Scientific American·A L Notkins
Jan 2, 1982·Lancet·J BertramsS Schoeps
Jul 17, 1980·The New England Journal of Medicine·E L ReinherzS F Schlossman
Feb 1, 1981·The American Journal of Medicine·J P Mordes, A A Rossini
Dec 25, 1980·The New England Journal of Medicine·H O McDevitt
Jun 11, 1981·The New England Journal of Medicine·G F Cahill, H O McDevitt
Jul 17, 1981·Deutsche medizinische Wochenschrift·J Bertrams, C Rittner
Jan 1, 1981·The American Journal of Medicine·W Gepts, P M Lecompte
Jan 1, 1981·The American Journal of Medicine·J Nerup, A Lernmark
Jul 17, 1981·Deutsche medizinische Wochenschrift·J BertramsK Jahnke
Jan 1, 1982·The Journal of Pediatrics·H F ChampsaurC Bach
May 1, 1980·Annals of Human Genetics·S E HodgeK L Lange
May 1, 1981·Immunology Today·G G Klaus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.