Pathogenesis and management of Kawasaki disease.

Expert Review of Anti-infective Therapy
Anne H Rowley, Stanford T Shulman

Abstract

Kawasaki disease (KD) is an acute systemic inflammatory illness of young children that can result in coronary artery aneurysms, myocardial infarction and sudden death in previously healthy children. Clinical and epidemiologic features support an infectious cause, but the etiology remains unknown four decades after KD was first identified by Tomisaku Kawasaki. Finding the cause of KD is a pediatric research priority. We review the unique immunopathology of KD and describe the current treatment. New research has led to identification of viral-like cytoplasmic inclusion bodies in acute KD tissues; this finding could lead to identification of the elusive etiologic agent and result in significant advances in KD diagnosis and treatment. Current management of acute KD is based upon prospective, multicenter treatment trials of intravenous immunoglobulin (IVIG) with high-dose aspirin. Optimal therapy is 2 g/kg IVIG with high-dose aspirin as soon as possible after diagnosis during the acute febrile phase of illness, followed by low-dose aspirin until follow-up echocardiograms indicate a lack of coronary abnormalities. The addition of one dose of intravenous pulse steroid has not been shown to be beneficial. For the 10-15% of patients wit...Continue Reading

References

Aug 7, 1986·The New England Journal of Medicine·J W NewburgerS P Sanders
Oct 1, 1993·The Journal of Pediatrics·R P SundelJ W Newburger
Feb 1, 1997·International Archives of Allergy and Immunology·J HiraoT Ichimura
Oct 2, 1997·Pediatrics·P A ChecchiaS T Shulman
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A H RowleyS C Baker
Jul 27, 2001·The American Journal of Cardiology·A M McMorrow TuohyL L Minich
Aug 31, 2001·The Journal of Infectious Diseases·T J BrownA H Rowley
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·M IshiiUNKNOWN Research Committee of Ministry of Health, Labour and Welfare--"Study of treatment and long-term management in Kawasaki disea
Apr 2, 2002·Pediatric Cardiology·N GotteinerS T Shulman
May 15, 2002·The Journal of Pediatrics·Shirley M L TseRae S M Yeung
Apr 15, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Patrick J GavinAnne H Rowley
Sep 2, 2003·Pediatrics·Robert C HolmanLawrence B Schonberger
Apr 8, 2004·The Journal of Pediatrics·Hiromi MutaToyojiro Matsuishi
May 8, 2004·The Pediatric Infectious Disease Journal·Alexandra F Freeman, Stanford T Shulman
Jul 24, 2004·The Journal of Infectious Diseases·Anne H RowleySusan E Crawford
Dec 3, 2004·Pediatrics·Jane W NewburgerUNKNOWN Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American H
Dec 17, 2004·The Pediatric Infectious Disease Journal·Masaru MiuraAnne H Rowley
May 5, 2005·The Journal of Pediatrics·Jane C BurnsMarian E Melish
Sep 1, 2005·Pediatric Cardiology·A F FreemanA H Rowley
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne H RowleySusan C Baker
Dec 13, 2006·Journal of Human Genetics·Yoshihiro OnouchiAkira Hata
Feb 16, 2007·The New England Journal of Medicine·Jane W NewburgerUNKNOWN Pediatric Heart Network Investigators
Mar 28, 2008·Nature Reviews. Microbiology·Anne H RowleyStanford T Shulman
Jul 19, 2008·Journal of Epidemiology·Yosikazu NakamuraHiroshi Yanagawa
Aug 2, 2008·The Journal of Pediatrics·Jane C BurnsOctavio Ramilo
Jan 10, 2009·PLoS Genetics·David BurgnerUNKNOWN International Kawasaki Disease Genetics Consortium
Feb 5, 2009·Pediatric Research·Yoshihiro Onouchi

❮ Previous
Next ❯

Citations

Nov 1, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jingjing ChenZubo Wu
Sep 22, 2011·Cardiology in the Young·Lydia KossivaKaravanaki Kyriaki
Jul 22, 2011·Pediatric Rheumatology Online Journal·Fernanda FalciniDonato Rigante
Apr 2, 2014·Journal of General Internal Medicine·Kara BischoffHarry Hollander
Nov 8, 2011·Indian Journal of Pediatrics·Fang-Liang HuangPo-Yen Chen
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Maria Teresa Terreri, Gleice Clemente
Jul 28, 2013·The Surgical Clinics of North America·William Wu, Rabih A Chaer
May 10, 2011·Autoimmunity Reviews·Iliana AlexoudiGeorge Vaiopoulos
Nov 26, 2010·Otolaryngologic Clinics of North America·Nadim M IslamDonald M Cohen
Aug 20, 2010·Clinical and Experimental Immunology·S JiaY Zu
Jan 10, 2013·Scandinavian Journal of Immunology·X GeG-B Wang
Jul 22, 2014·Clinical and Experimental Immunology·F-F NiJ Yang
Apr 16, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·UNKNOWN Research Committee of the Japanese Society of Pediatric Cardiology, UNKNOWN Cardiac Surgery Committee for Development of Guidelines for Medical Treatment of Acute Kawasaki Disease
Nov 28, 2013·International Journal of Pediatrics·Nathan Jamieson, Davinder Singh-Grewal
Dec 20, 2011·Neuroscience Letters·Ryoji IdeShigeji Matsumoto
Dec 3, 2014·The American Journal of Medicine·Pranas SerpytisVioleta Panaviene
Mar 12, 2013·Case Reports in Pediatrics·Samin AlaviArmin Rashidi
Mar 14, 2013·Korean journal of pediatrics·Hyo Min ParkSang Bum Lee
Sep 10, 2016·Korean journal of pediatrics·Hyun Jung KimHong Ryang Kil
Oct 27, 2015·BMC Musculoskeletal Disorders·Yan DingLei Zhao
Jan 22, 2017·Clinical and Experimental Medicine·Feifei SiQijian Yi
Jul 29, 2018·Clinical and Experimental Medicine·Ya SuQijian Yi
Sep 17, 2016·Journal of the American Heart Association·Kevin G FriedmanJane W Newburger
Jun 1, 2018·BMJ Case Reports·Nichkamol Lertamornkitti, Anchalee Wangjirapan
Mar 23, 2019·Biomarkers in Medicine·Moises Rodriguez-GonzalezHelena M Cascales-Poyatos
Jan 10, 2020·Expert Review of Anti-infective Therapy·Ling-Sai Chang, Ho-Chang Kuo
Feb 6, 2020·Current Rheumatology Reports·Priya R SoniMoshe Arditi
Jul 29, 2020·Inflammatory Bowel Diseases·Franco ScaldaferriAlessandro Armuzzi
Apr 24, 2020·Journal of Immunology Research·Chao LiuGuijian Liu
Feb 20, 2018·World Journal of Clinical Pediatrics·Rakesh Kumar PilaniaSurjit Singh
Aug 6, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Ho-Chang KuoLien-Hung Huang
Mar 23, 2020·Clinical Reviews in Allergy & Immunology·Rajni KumrahSurjit Singh
Jul 31, 2018·Journal of Investigative Medicine High Impact Case Reports·Neetu BoodoosinghNaveen Anand Seecheran
Jul 3, 2019·Frontiers in Immunology·Stephanie MenikouMichael Levin
Jan 5, 2021·Frontiers in Immunology·Despina MichailidouChristian Lood
Dec 18, 2020·Frontiers in Pediatrics·Charlotte V HobbsWilliam Borkowsky
Feb 21, 2021·World Journal of Pediatrics : WJP·Eman A ToraihEmad Kandil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.